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Lisebelisuoa tse Rekoang ka ho Fetisisa tsa Ritonavir Anti-Virus
Tlhaloso e Felletseng
Ritonavir, setlhare sa antiretroviral, hangata se sebelisoa hammoho le litlhare tse ling ho alafa HIV/AIDS. Kalafo ena e kopantseng, e tsejoang ka hore ke kalafi e sebetsang haholo ea li-antiretroviral (HAART), e ipakile e sebetsa ho laola boemo. Ritonavir e thathamisitsoe e le protease inhibitor, empa mosebetsi oa eona oa mantlha hajoale ke ho matlafatsa matla a li-protease inhibitors tse ling.
Ntle le ts'ebeliso ea eona kalafong ea HIV/AIDS, ritonavir e boetse e sebelisitsoe hammoho le litlhare tse ling ho alafa lefu la sebete la C le, haufinyane tjena, COVID-19. E nkoa ka molomo ka mokhoa oa matlapa kapa li-capsules. Ke habohlokoa ho hlokomela hore bioavailability ea lipilisi le li-capsules tsa ritonavir li ka 'na tsa fapana,' me matlapa a ka 'na a baka khatello e phahameng ea "plasma" e phahameng. Le hoja qalong e ntlafalitsoe e le sethethefatsi se ikemetseng sa antiviral, e bontšitse thepa e molemo haholoanyane ha e sebelisoa mekhoeng e kopantsoeng le ritonavir ea tekanyo e tlase le li-protease inhibitors tse ling. Matsatsing ana, e sebelisoa haholo-holo e le matlafatso ea li-protease inhibitors tse ling. E fumaneha ka mokhoa oa metsi le ka li-capsules.
Tšebeliso ea mantlha ea ritonavir ke kalafong ea bakuli ba nang le HIV, haholo Mofuta oa 1, e leng mofuta o kotsi le o atileng haholo. Hangata e kopantsoe le moriana o mong oa antiretroviral o bitsoang lopinavir ho ntlafatsa katleho ea kalafo. Lopinavir le ritonavir li sebetsa 'moho ho thibela le ho fokotsa tlhahiso ea kokoana-hloko ea HIV 'meleng. Leha ho le joalo, ho bohlokoa ho utloisisa hore lopinavir le ritonavir ha se pheko ea HIV ebile ha li thibele phetiso ea vaerase ho tloha ho motho e mong ho ea ho e mong.
Ha e sebelisoa hammoho le meriana e meng ea HIV, ritonavir e thusa ho laola tšoaetso ea HIV ka ho fokotsa bongata ba HIV 'meleng. Sena, ka lehlakoreng le leng, se ntlafatsa ts'ebetso ea sesole sa 'mele, se fokotsa kotsi ea mathata le ho ntlafatsa boleng ba bophelo ka kakaretso. Ritonavir ke ea sehlopha sa li-protease inhibitors 'me e sebetsa ka ho eketsa maemo a li-protease inhibitors tse ling, kahoo e matlafatsa ts'ebetso ea tsona. Ho bohlokoa hore bakuli ba hlokomele hore ritonavir ha e phekole tšoaetso ea HIV. Ho fokotsa kotsi ea ho fetisetsa lefu lena, ho bohlokoa ho latela mokhoa o behiloeng oa meriana ea HIV. Ho feta moo, ho sebelisa mekhoa e sebetsang ea lithibelo joalo ka likhohlopo tsa latex kapa polyurethane nakong ea thobalano le ho qoba ho arolelana lintho tseo e kanna eaba li kopane le mali kapa maro a 'mele ke mehato ea bohlokoa eo u ka e nkang.
Ritonavir, eo qalong e hlahisitsoeng e le inhibitor ea HIV protease, ha se hangata e sebelisetsoang tšebetso ea eona ea antiviral. Ho e-na le hoo, e sebelisoa haholo e le matlafatso ea li-protease inhibitors tse ling. Ritonavir e thibela enzyme e tsejoang e le cytochrome P450-3A4 (CYP3A4), e ikarabellang bakeng sa metabolizing protease inhibitors. Ka ho tlama le ho thibela CYP3A4, ritonavir e nolofalletsa ho sebelisoa ha litekanyetso tse ling tsa protease inhibitors, ho ntlafatsa katleho ea tsona le ho fokotsa liphello tse mpe. Leha ho le joalo, ke habohlokoa ho hlokomela hore thibelo ea CYP3A4 e ka boela ea ama katleho ea meriana e meng, ea baka mathata ha u fana ka lithethefatsi ka nako e le 'ngoe.
Ka bokhuts'oane, ritonavir ke karolo ea bohlokoa ea kalafo ea HIV/AIDS, e sebetsa joalo ka protease inhibitor le booster ea li-protease inhibitors tse ling. Tšebeliso ea eona e ka sehloohong ke ho phekola HIV, haholo-holo Mofuta oa 1. Le hoja e thusa ho laola tšoaetso ea HIV le ho ntlafatsa boleng ba bophelo, ha se pheko ebile ha e thibele phetiso ea kokoana-hloko. Ho utloisisa ts'ebetso ea meriana le ho latela mekhoa e behiloeng ea kalafo ho bohlokoa bakeng sa ho laola boemo ka nepo.
Ka bokhuts'oane, ritonavir ke karolo ea bohlokoa ea kalafo ea HIV/AIDS, e sebetsa joalo ka protease inhibitor le booster ea li-protease inhibitors tse ling. Tšebeliso ea eona e ka sehloohong ke ho phekola HIV, haholo-holo Mofuta oa 1. Le hoja e thusa ho laola tšoaetso ea HIV le ho ntlafatsa boleng ba bophelo, ha se pheko ebile ha e thibele phetiso ea kokoana-hloko. Ho utloisisa ts'ebetso ea meriana le ho latela mekhoa e behiloeng ea kalafo ho bohlokoa bakeng sa ho laola boemo ka nepo.
Tlhaloso
