Triptorelin, decapeptide ea maiketsetso le analog ea gonadotropin-release hormone (GnRH) ea tlhaho, e fumane kananelo e kholo lefapheng la bongaka. E sebelisoa bakeng sa matšoao a fapaneng, ho kenyelletsa kalafo ea endometriosis, fibroids, mofetše oa senya, ho kena bonneng kapa bosaling pele ho nako, le ho hloka thari. Triptorelin e sebetsa ka ho hlohlelletsa tlhahiso ea li-gonadotropin mme ka mor'a moo e theole li-receptor tsa li-gonadotropin tse lokollang li-hormone, e leng se bakang phokotso ea nako e telele ea tokollo ea gonadotropin.
Triptorelin e bonts'a mefuta e mengata ea litlamorao tsa kalafo. Ho basali, e sebelisoa ho laola endometriosis, uterine fibroids le ho hloka thari. Tsamaiso e tsoelang pele ea Triptorelin e thibela ka katleho tlhahiso ea estradiol, e lebisang ho hatelletsoeng ha lisele tsa ectopic endometrial ho endometriosis. Ho feta moo, liphuputso li bonts'itse phokotso e kholo ea boholo ba uterine fibroids, mme bakuli ba bangata ba na le amenorrhea kamora khoeli ea pele ea kalafo. Bakeng sa ho hloka thari, triptorelin e thibela secretion ea gonadotropins, e ntlafatsa boleng ba tlhahiso ea follicle le ho eketsa palo ea follicles, ka tsela eo e eketsa menyetla ea ho atleha ho thusa mekhoa ea ho ikatisa joalo ka in vitro fertilization.
Ho banna, triptorelin e sebelisoa hangata bakeng sa taolo ea mofetše oa tšoelesa ea senya. E sebetsa ka ho qala ka ho eketsa maemo a hormone ea luteinizing (LH) le maemo a follicle-stimulating hormone (FSH), e lateloa ke ho fokotseha ha lihomone tsena le ho fokotseha ha maemo a testosterone maling. Phokotso ena ea maemo a testosterone e thusa kalafong ea mofetše oa senya le matšoao a amanang le ona. Liente tsa Triptorelin le tsona li sebelitse kalafo ea ho kena bohlankaneng pele ho nako, ho thibela pituitary hypersecretion ea gonadotropin le maemo a tloaelehileng a lihormone.
Mekhoa ea ts'ebetso ea triptorelin e kenyelletsa ka bobeli khatello ea secretion ea gonadotropin le inhibition e tobileng ea gonadotropic ka ho senya li-receptor tsa GnRH. Lithuto tsa liphoofolo le tsa batho li bonts'itse litlamorao tse thibelang ts'ebeliso ea nako e telele ea triptorelin ho secretion ea gonadotropin, e lebisang ho hatelleheng ha tšebetso ea testicular le mae a bomme. Ts'ebetso ea Triptorelin e boetse e pakoa ke ntlafatso ea kliniki matšoao a kang dysmenorrhea, bohloko bo sa foleng ba pelvic, le bohloko nakong ea thobalano.
Re fana ka mefuta e fapaneng ea litharollo tse ikhethileng tseo u ka khethang ho tsona
Ente ea Triptorelin: 0.1 mg/1 ml.
Ente e atolositsoeng ea Triptorelin: 3.75 mg; 11,25 mg; 22.5 mg.
Triptorelin pamoate bakeng sa ente: 15 mg ka botlolo (e nang le botlolo e le 'ngoe ea 2 ml solvent). Haeba u na le litlhoko tse ling, u ka boela ua ikopanya le rona 'me re tla u fa litšebeletso tsa hang-hang le tse nepahetseng.
Joalo ka analog e matla ea gonadotropin, Triptorelin e fana ka mefuta e mengata ea likopo tsa kalafo bakeng sa banna le basali. Bokhoni ba eona ba ho laola maemo a lihormone le ho thibela secretion ea gonadotropin e ipakile e sebetsa taolong ea maemo a kang endometriosis, uterine fibroids, mofets'e oa senya, ho kena bohlankaneng pele ho nako le ho hloka thari. Ka katleho ea eona ea kliniki le ho feto-fetoha ha maemo, triptorelin e ntse e tsoela pele ho kenya letsoho haholo lefapheng la meriana ea ho ikatisa le oncology.Ho utloisisa mekhoa ea ts'ebetso le litokisetso tse teng tsa triptorelin ho lumella litsebi tsa tlhokomelo ea bophelo ho hlophisa merero ea phekolo ho latela litlhoko tsa mokuli ka mong.
