0102030405
Vincristine Sulfate Powder Vincristine Purity Vincristine CAS 57-22-7
Tlhaloso e Felletseng
Vincristine ke phofo ea kristale e tšoeu ho ea ho e tšoeu. E batla e sa qhibilihe ka metsing, empa e qhibiliha ka har'a metsoako e meng ea tlhaho.Motsoako o hloekileng ha o na monko 'me ka tloaelo o bolokiloe sebakeng se omileng, se lefifi tlas'a maemo a laoloang a mocheso ho boloka botsitso ba oona. Ke alkaloid ea tlhaho e tsoang semela sa periwinkle sa Madagascar (Catharanthus roseus). Sebopeho sa eona sa lik'hemik'hale se tšoana le sa vinblastine, alkaloid e 'ngoe ea vinca.Vincristine e sebelisoa haholo ho phekola mefuta e sa tšoaneng ea kankere, ho akarelletsa leukemia, lymphoma, le lihlahala tse tiileng. .
Vincristine ke microtubule inhibitor e sitisang sebopeho sa li-microtubules, tseo e leng likarolo tsa bohlokoa tsa cytoskeleton ea sele. Ka ho tlama tubulin, e thibela ho kopana ha li-microtubules, ho lebisang ho ts'oaroe ha mitotic le lefu la lisele liseleng tse arohaneng ka mafolofolo. Vincristine e sebetsa ka ho khetheha khahlanong le lisele tsa mofetše tse arohaneng ka potlako.Litšebeliso tsa bongaka tsa vincristine li kenyelletsa phekolo ea mafu a sa tšoaneng a kang acute lymphoblastic leukemia(ALL),Hodgkin's le non-Hodgkin's lymphomas, lihlahala tsa bana le tsa batho ba baholo,neuroblastoma,le rhabdomyosarcoma.Vincristine e atisa ho sebelisoa. mmoho le dikhemikhale tse ding e le karolo ya kalafo ya dithethefatsi tse ngata, e tsejwang ka kopanelo e le chemotherapy e kopantseng.
Ntle le ts'ebeliso ea eona ea mantlha kalafong ea mofets'e, vincristine e boetse e bonts'itse katleho taolong ea maemo a mang ao e seng a oncological. E sebelisoa kalafong ea idiopathic thrombocytopenic purpura(ITP), lefu la autoimmune le khetholloang ke palo e tlase ea liplatelete. ,vincristine e bontšitse bokhoni ba ho laola maemo a fapaneng a methapo ea kutlo, ho kenyelletsa le mafu a sa foleng a demyelinating polyneuropathy(CIDP) le mafu a bana a autoimmune neuropsychiatric a amanang le mafu a streptococcal(PANDAS).
Ho feta moo, thepa ea vincristine ea anti-angiogenic e lebisitse ho lekolloe ts'ebeliso ea eona e ka bang teng kalafong ea mafu a fapaneng a ho ata, ho kenyelletsa retinopathy ea lefu la tsoekere le degeneration e amanang le lilemo. maemo a mang a bongaka a nkoa a le sieo 'me a hloka tlhahlobo e hlokolosi ea likotsi le melemo e ka bang teng.Ka kakaretso, vincristine, e nkiloeng ho semela sa Madagascar periwinkle, ke moemeli oa bohlokoa o thibelang mofetše o sitisang sebopeho sa microtubule le ho etsa hore lisele li shoe liseleng tse arolang. lits'ebetso tse fapaneng tsa kliniki li kenyelletsa kalafo ea leukemia, lymphoma, lihlahala tse tiileng, le maemo a itseng a seng a oncological.Le hoja tšebeliso ea eona ea mantlha e le kalafo ea mofets'e, lipatlisiso tse tsoelang pele li ntse li tsoela pele ho hlahloba bokhoni ba eona maemong a fapaneng a bongaka.
Tlhaloso
