I-Abaloparatide, ithengiswa phantsi kwegama le-brand iTymlos, i-analog yokwenziwa kweprotein ehlobene ne-hormone ye-parathyroid (PTHrP). I-agent ye-anabolic esetyenziselwa ukuphatha i-osteoporosis, imeko ebonakaliswe ngamathambo abuthathaka kunye nomngcipheko okhulayo wokuphuka. I-Abaloparatide ibonakaliswe kubafazi be-postmenopausal kunye namadoda ane-osteoporosis emngciphekweni omkhulu wokuphuka, kunye nalabo abangaphumelelanga okanye abangenakunyamezelwa kwezinye iindlela zonyango ezifumanekayo ze-osteoporosis. Ngokukhetha ngokukhetha i-hormone ye-parathyroid i-1 receptor (PTH1R), i-abaloparatide ikhuthaza ukukhula kwamathambo kunye nokwandisa ukuxinana kwamathambo.
I-Abaloparatide yi-34 amino acid analog synthetic ye-PTHrP, kunye ne-41% ye-homology kwi-hormone ye-parathyroid (PTH) (1-34) kunye ne-76% ye-homology kwi-PTHrP (1-34). Indlela yokusebenza kwayo ibandakanya ukubopha kwi-PTH1R, i-G protein-coupled receptor echazwe kwi-osteoblasts kunye ne-osteocytes. Ngokuzibophelela ngokukhethekileyo kwimo ye-RG ehambelanayo ye-PTH1R, i-abaloparatide ifuna impendulo yomqondiso we-AMP yethutyana esezantsi, ekhokelela kwindlela yomqondiso we-anabolic.
Kwabasetyhini abasemva kokumenopausal abane-osteoporosis abasengozini enkulu yokwaphuka, i-abaloparatide lukhetho olusebenzayo lonyango. Inceda ukwandisa ubunzima bamathambo kunye nokunciphisa umngcipheko wokuphuka. Ukongezelela, i-abaloparatide ingasetyenziselwa ukunyusa ukuxinana kwamathambo kumadoda ane-primary okanye i-hypogonadal osteoporosis asengozini enkulu yokuphuka okanye ayiphumelelanga okanye ayinyamezeliyo kwezinye iindlela zonyango ezikhoyo.
Ngaphaya koko, i-abaloparatide ibonelela ngeenzuzo kumadoda nabasetyhini abane-osteoporosis ehambelana nonyango oluzinzileyo lwe-glucocorticoid. Aba bantu basengozini enkulu yokwaphuka ngenxa yokusetyenziswa kwexesha elide leglucocorticoids. I-Abaloparatide inokunceda ukuphucula amandla ethambo kunye nokunciphisa umngcipheko wokuphuka kule ndawo ethile.
I-Abaloparatide, i-analog yokwenziwa ye-PTHrP, yonyango oluxabisekileyo lwe-osteoporosis. Iimpawu zayo ze-anabolic zikhuthaza ukukhula kwamathambo kunye nokwandisa ukuxinana kwamathambo, ukunciphisa umngcipheko wokuphuka. Kuboniswa kubafazi be-postmenopausal kunye namadoda asemngciphekweni omkhulu wokuphuka, kunye nabantu abangaphumeleliyo okanye abangenakunyamezelwa kwezinye iindlela zonyango ze-osteoporosis. Ngokukhetha ngokukhetha i-PTH1R, i-abaloparatide ibangela indlela yokubonisa i-anabolic eyandisa impilo yamathambo. Ukusetyenziswa kwayo kwi-osteoporosis ehambelana ne-systemic glucocorticoid therapy inika ukhetho olubalulekileyo lonyango kubantu abasengozini enkulu yokuphuka. I-Abaloparatide idlala indima ebalulekileyo ekujonganeni neemfuno zezigulane ezine-osteoporosis kunye nokuphucula impilo yamathambo kunye nomgangatho wobomi.
