I-Arecoline hydrobromide yoNyango olunokubakho kwi-Central nervous system

Ixabiso leReferensi: USD15-20/g

Igama lemveliso Arecoline
Inombolo yeCAS. 300-08-3
MF C8H14BrNO2
MW 236.109
EINECS 206-087-3
I-acidity coefficient (pka) 6.84(nge-25℃)
Indawo yokunyibilika 171-175°C

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I-Arecoline, inqununu esebenzayo ye-alkaloid efunyenwe kwi-areca nut, ifumene ingqalelo kumandla ayo onyango ekujonganeni nokuphazamiseka kwengqondo kunye nokunciphisa izifo zesisu. Eli nqaku lijolise ekunikezeni isishwankathelo esicwangcisiweyo sendlela yokusebenza kwe-arecoline kwiinkqubo ezahlukeneyo zomzimba, kubandakanywa nomlomo womlomo, inkqubo ye-nervous central, inkqubo ye-cardiovascular system, kunye ne-digestive system. Ukongeza, imisebenzi yezempilo kunye neziphumo ezinobuthi ze-arecoline ziya kuphononongwa. Okokugqibela, usetyenziso lwe-arecoline kwizongezo zokutya kwezempilo, amayeza, kunye namalungiselelo okuthambisa kuya kuxoxwa.

I-Arecoline, i-nicotinic acid-based mild parasympathomimetic stimulant alkaloid, ngokuyinhloko isebenza njenge-agonist inxalenye ye-muscarinic acetylcholine receptors. Ibonisa iziphumo ze-parasympathetic endaweni ye-nicotinic acetylcholine receptors efana ne-nicotine. I-Arecoline iphinda inqanda i-AMPK (i-adenosine monophosphate-activated protein kinase) ngokuvelisa iintlobo ze-oksijini ezisebenzayo (ROS) kwiintlobo zeeseli ezahlukeneyo.

Iimpembelelo kwiiNkqubo zoMzimba owahlukileyo:

I-Nervous System: I-Arecoline ikhuthaza ukuvuselela, iphakamisa ukufunda kunye nememori, kwaye iyancipha iimpawu zokudakumba kunye ne-schizophrenia. Iyakwazi ukubuyisela umva ukulahleka kwememori okubangelwa yi-scopolamine.

I-Cardiovascular System: I-Arecoline isebenza njenge-vasodilator, inyusa i-plasma nitric oxide, i-eNos, kunye ne-mRNA ibonakaliso, kwaye ibonisa i-anti-thrombosis kunye ne-anti-atherogenic effects. Ikwanciphisa i-IL-8 kunye nezinye izinto.

Inkqubo ye-Endocrine: I-Arecoline ivuselela iiseli zeLeydig, ezikhokelela ekunyuseni kwamanqanaba e testosterone. Ivuselela i-hypothalamic-pituitary-adrenal (HPA) axis, ivuselela ukukhululwa kwe-corticotropin-releasing hormone (CRH). Ukongeza, inceda ukuthintela ukungasebenzi kakuhle kweeseli ze-pancreatic beta ezibangelwa kukutya okuphezulu kwe-fructose.

I-Digestive System: I-Arecoline ivuselela inkqubo yokugaya ngokusetyenziswa kwe-muscarinic receptors. Iyakwandisa ukucutshungulwa kwemisipha egudileyo yesisu kunye nemicu yemisipha ye-duodenum, ileum, kunye nekholoni.

Imisebenzi yezempilo kunye nezicelo:

I-Analgesia kunye ne-Central Nervous System Effects: I-Arecoline hydrobromide ibonisa iimpawu ze-analgesic kwaye inefuthe lokuzinzisa kwinkqubo ye-nervous central.

Impilo yesikhumba: I-Arecoline hydrobromide ikhuthaza i-metabolism yolusu kwaye ibonisa amandla okunyanga izilonda zesikhumba kunye nezinye izifo zesikhumba.

I-Detoxification kunye ne-Diuretic Effects: I-Arecoline hydrobromide isusa ukushisa, ikhupha, ikhuphe ubumanzi kunye nokudumba, kwaye ineempawu ze-diuretic.

I-Antibacterial kunye ne-Dissolving Stones: I-Arecoline hydrobromide ibonisa iimpawu ze-antibacterial kunye nokukwazi ukunyibilikisa amatye.

Ukuqiniswa kweMithi yeGazi kunye nokujikeleza kwegazi: I-Arecoline hydrobromide inceda ukuqinisa imithwalo yegazi kunye nokukhuthaza ukujikeleza kwegazi.

Usetyenziso:

Izongezo zokutya kweMpilo: I-Arecoline ingasetyenziswa njengesithako kwizongezo zokutya okunempilo ezijolise kwimisebenzi ethile yempilo, njengokuphucula ingqiqo okanye impilo yesikhumba.

I-Pharmaceuticals: I-Arecoline inokuba nezicelo ezinokuthi zenze kumachiza, ngokukodwa kunyango lwezifo zengqondo okanye njengeyeza le-antihelmintic.

Ukulungiswa kwe-Cosmetic: Ukukhuthazwa kwe-Arecoline ye-metabolism yolusu kunye neempawu zokuphulukisa amanxeba ezinokuthi zibe ngumviwa wamalungiselelo okuthambisa, ngakumbi abo bajolise kwizilonda zesikhumba okanye ezinye izifo ezinxulumene nolusu.

I-Arecoline, i-alkaloid esebenzayo efumaneka kwi-areca nut, ibonisa iziphumo ezahlukeneyo zonyango kwaye inezicelo kwiinkqubo ezahlukeneyo zomzimba. Iindlela zayo zokwenza ngokuyintloko zixutywe nge-muscarinic receptors kwaye zibonise imiphumo ye-parasympathetic. Nangona i-arecoline ibonisa isithembiso ekujonganeni neemeko ezithile zempilo, kubalulekile ukuqwalasela iziphumo ezinobuthi ezinobuthi kunye neempawu ze-carcinogenic ezinxulumene nokusetyenziswa kwayo.Qhagamshelana nathi ukuba ufuna.

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