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ICisplatin, ekwabizwa ngokuba yiPlatinol, liyeza lechemotherapy elisetyenziselwa ukunyanga iintlobo ezahlukeneyo zomhlaza.
Imbonakalo: I-Cisplatin ngumgubo wekristale omhlophe ukuya kumhlophe kunye nevumba elibi elibonakalayo.Ayinyibiliki kancinci emanzini kodwa inyibilika kwizisombululo ezinechloride kunye nezinye izinyibilikisi eziphilayo.Ikhompawundi esulungekileyo igcinwa kwindawo eyomileyo, emnyama phantsi kolawulo iimeko zobushushu ukugcina uzinzo.Xa igcinwe ngokufanelekileyo, i-cisplatin igcina ingqibelelo yayo yeekhemikhali kunye potency.Yaqala ukwenziwa ngo-1844 nguAlfred Werner, usokhemisti waseSwitzerland owafumana ibhaso leNobel kwiKhemistry ngo-1913 ngomsebenzi wakhe kwi-coordination compounds. kamva yaphandwa ngeempawu zayo zokulwa nomhlaza kwaye yafunyanwa iyasebenza kunyango lwezifo ezahlukeneyo.
Umsebenzi kunye nezicelo: I-Cisplatin ihlelwe njenge-platinum-based based chemotherapy drug kwaye iyinxalenye yentsapho ye-alkylating agents.Isebenzisa imiphumo yayo ye-anticancer ngokwenza i-covalent bonds kunye ne-DNA, ekhokelela ekuphazamisekeni kwemisebenzi yeselula kwaye ekugqibeleni ibangele ukufa kweseli. Ngokukodwa. , i-cisplatin ibophelela kwiziseko ze-purine kwi-DNA, zenza i-intrastrand kunye ne-interstrand crosslinks.Ezi ziphambano ziphazamisa ukuphindaphinda kwe-DNA kunye nokubhala, okukhokelela ekuvinjweni kwe-cell proliferation kunye nokufakwa kwe-apoptosis kwiiseli zomhlaza.I-Cisplatin isetyenziswa ngokubanzi kunyango lweentlobo ezahlukeneyo iintlobo zomhlaza, kubandakanywa i-testicular, i-ovarian, isinyi, intloko nentamo, imiphunga kunye nomhlaza womlomo wesibeleko.
Idla ngokuba yinxalenye yeerejimeni zechemotherapy ezidityanisiweyo kwaye ilawulwa ngemithambo kwindawo yeklinikhi phantsi kweliso labasebenzi bezempilo.Ukudibanisa i-cisplatin kunye nezinye i-chemotherapeutic agents, ezifana ne-etoposide, i-bleomycin, kunye ne-fluorouracil, ibonise iziphumo ze-synergistic kunyango oluthile. Ukongeza kwindima yayo ephambili kunyango oluluqilima lwethumba, i-cisplatin ikwasetyenziswa kunyango lwamathumba eseli yentsholongwane, zombini njengearhente enye kwaye idityaniswe namanye amayeza echemotherapy. ngakumbi xa isetyenziswe ngokudityaniswa nezinye ii-agent ezisekelwe kwiplatinam ezifana ne-etoposide kunye ne-bleomycin.Ngaphezu koko, i-cisplatin iye yaphononongwa ukuze isetyenziswe kwezinye iindidi zomhlaza, kubandakanywa umhlaza wommizo, wesisu kunye nomhlaza wepancreatic.
Uphando luyaqhubeka nokuphonononga ukusebenza kwalo ngokudibeneyo kunye nonyango olujoliswe kuyo kunye ne-immunotherapies ukunyusa iziphumo zonyango kunye nokunciphisa uphuhliso lokunganyangeki. Ngaphandle kokunyangwa komhlaza, i-cisplatin iphandwe ngokusetyenziswa kwayo kunyango lwe-hyperthermia yendawo, ebandakanya ukufudumeza iindawo ezithile zomhlaza. Umzimba ukubulala iiseli zomhlaza okanye ukubenza babe buthathaka ngakumbi kolunye unyango. Kulo mxholo, i-cisplatin isetyenziswa ngokudityaniswa nobushushu ukunyusa iziphumo zayo ze-cytotoxic ngaphakathi kwe-tumor microenvironment.
Isishwankathelo, i-cisplatin sisiyobisi se-chemotherapy esekwe kwiplatinam esenza iziphumo zayo zokulwa nomhlaza ngokwenza i-DNA crosslinks kwaye ibangele ukufa kweeseli kwiiseli zomhlaza. Izicelo zayo ezixhaphakileyo zeklinikhi ziquka unyango lwe-testicular, ovarian, isinyi, intloko kunye nentamo, imiphunga, kunye Umhlaza womlomo wesibeleko, kunye nophando oluqhubekayo oluphonononga amandla alo kwezinye izifo ezinobungozi.Ukongezelela, i-cisplatin inezicelo ezinokubakho kwi-hyperthermia therapy kwaye iyaqhubeka iyingxenye ebalulekileyo yokudibanisa i-chemotherapy regimens.
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