Inkcazo eneenkcukacha
I-Clomiphene, ichiza elivunywe yi-FDA elisetyenziswa ikakhulu kwiingxaki zokuzala kwabasetyhini, ngokwesiko belithathwa njengelingawafanelanga amadoda. Nangona kunjalo, iingcali zokusika ziye zafumanisa ukusetyenziswa okunokwenzeka kwe-clomiphene kumadoda anezibalo eziphantsi zesidoda ezibangelwa yimiba yemfuza okanye ukusetyenziswa kwe-steroid. Ukongeza, abakhi bomzimba abangamadoda baye baqala ukusebenzisa i-clomiphene njengeyeza lokugcina i-testosterone ukukhulisa ukukhula kwemisipha. Sinikezela ngombono wendlela yokwenza i-clomiphene, iziphumo zayo kumanqanaba ehomoni, kunye neenzuzo zayo ezinokuthi zibe nobungozi kumadoda.
I-Clomiphene yaziwa ngokuchaphazela i-estrogen axis emzimbeni, nangona indlela yokusebenza kwayo ihlala ingaqondakali. Isebenzisana ne-estrogen receptors kwizicubu ezahlukeneyo, kubandakanywa i-hypothalamus, i-pituitary gland, ii-ovari, i-endometrium, i-vagina, umlomo wesibeleko, i-adrenal glands, i-peripheral adipose tissue, isibindi kunye neestes. Kwabasetyhini, i-clomiphene ngokuyintloko isebenza kwi-hypothalamus kunye ne-pituitary gland, ivuselela i-secretion ye-gonadotropin-releasing hormone (GnRH), i-follicle-stimulating hormone (FSH), kunye ne-luteinizing hormone (LH). Oku kukhuthazwa kukhuthaza i-ovulation. Kumadoda, i-clomiphene iphinda isebenze kwi-hypothalamus kunye ne-pituitary gland, ekhokelela ekunyuseni kwemveliso ye testosterone kunye nesidoda.
Ngokuchasene nenkolelo eyaziwayo, i-clomiphene ayinciphisi amanqanaba e-estrogen emzimbeni. Ngapha koko, inokukhuthaza ukukhutshwa kwe-estrogen kwinqanaba elithile emadodeni. Kubalulekile kubantu abasebenzisa i-clomiphene, ngokukodwa abakhi bomzimba besilisa, ukubeka iliso zombini amanqanaba e-testosterone kunye ne-estradiol ukuphepha imiphumo enokubakho efana ne-gynecomastia (ukwandiswa kwebele lesilisa).
Abakhi bomzimba besilisa bahlala besebenzisa i-clomiphene njenge-adjunct kwimijikelezo yabo ye-steroid. Nangona kunjalo, kubalulekile ukuba uqaphele ukuba i-clomiphene ayihlelwanga njengeziyobisi eziphuculisayo kwaye ayinayo imiphumo ye-androgenic. Ukusetyenziswa kwexesha elide le-clomiphene kumadoda kuye kwadibaniswa ne-macromastia (amabele awandisiweyo) kunye ne-testicular tumors, nangona ikhonkco ecacileyo ye-causal phakathi kwe-clomiphene kunye nale miphumo emibi ayizange isungulwe.
Ngelixa i-clomiphene isanda kusetyenziswa ngabakhi bomzimba besilisa kunye neembaleki, ukusebenza kwayo emadodeni kuhlala kungaqinisekanga ngenxa yezifundo ezilinganiselweyo. Kubalulekile ukuba ulumke xa ucinga ngokusetyenziswa kwe-clomiphene, ngakumbi xa kungekho bungqina bubambekayo. Ngaphezu koko, kuyacetyiswa ukuba udibane nochwepheshe bezempilo ngaphambi kokuba udibanise i-clomiphene kwirejimeni ye-steroid.
Izindululo:
indoda
I-Clomiphene isetyenziswe kwi-pct, kwi-dose ye-50-100 mg imihla ngemihla ngeentsuku ze-30 ukubuyisela imveliso ye-testosterone yendalo kumanqanaba aqhelekileyo. Oku kusetyenziswa ngokuqhelekileyo kuthathwa njengeyona nto ifanelekileyo njengenxalenye yenkqubo yokubuyisela emva komjikelo (jonga unyango lwe-PCT)
abadlali ababhinqileyo
I-Clomid ngamaxesha athile isetyenziselwa ukunciphisa i-estrogen ngaphambi kokukhuphisana kukhuphiswano lokwakha umzimba. Kwezinye iimeko, oku kunokunceda ukulahleka kwamafutha kunye nokukhuthaza ukukhula kwezihlunu, ngakumbi kwiindawo ezinengxaki zabasetyhini ezifana neempundu kunye namathanga. Nangona kunjalo, eli chiza lihlala lineziphumo ebezingalindelekanga ezikhathazayo kwabasetyhini abangaphambi kokuya esikhathini kwaye ke alifunwa kakhulu kweli qela.
I-Clomiphene, eyona nto isetyenziselwa iingxaki zokuzala kwabasetyhini, ifumene ingqalelo kusetyenziso lwayo olunokubakho kumadoda anezibalo eziphantsi zesidoda kwaye njengechiza lokugcinwa kwe testosterone kubakhi bomzimba besilisa. Indlela yokusebenza kwayo ibandakanya ukukhuthaza ukukhuselwa kwe-gonadotropins, ethi ikhuthaze i-ovulation kubasetyhini kunye nokuveliswa kwe-testosterone kumadoda. Nangona kunjalo, ukusebenza kunye nokukhuseleka kwe-clomiphene kumadoda kufuna uphando olongezelelweyo.
Khumbula ukuqhagamshelana nathi ukuze uhanjiswe ngokukhawuleza!
Inkcazo
