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I-Flumazenil I-Antagonist ekhethiweyo ye-GABAA ye-Receptor kunye nezicelo zayo zonyango
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Ixabiso leReferensi:USD 1-2/g

  • Igama lemveliso Flumazenil
  • Inombolo yeCAS. 78755-81-4
  • MF I-C15H14FN3O3
  • MW 303.288363
  • EINECS 616-650-9
  • Ukuxinana 1.39
  • Indawo yokunyibilika 201-203℃
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Inkcazo eneenkcukacha

I-Flumazenil, ekwabizwa ngokuba yi-flumazepil okanye igama lekhowudi ye-Ro 15-1788, ngumchasi okhethiweyo we-GABAA we-receptor onokulawulwa ngenaliti, ukufakwa kwe-otic, okanye intranasally. Isebenza njenge-antagonist kunye ne-antidote kwi-benzodiazepines, ngakumbi kwiimeko zokugqithisa ngokweqile, ngokunqanda ukhuphiswano. Eli nqaku liphonononga izibonelelo zonyango, ukusetyenziswa njenge-antidote, kunye nokusetyenziswa okunokwenzeka kwe-flumazenil kwiindawo ezahlukeneyo zonyango.

I. Indlela yokwenza:
A. I-GABAA ekhethiweyo ye-receptor antagonist
B. Ukuthintela ukhuphiswano kwindawo yokuqaphela i-benzodiazepine
C. Ukuguqulwa kwemiphumo ye-benzodiazepine

II. I-Antidote ye-Benzodiazepine Overdose:
A. Ukubaluleka kokuthintela okukhuphisanayo kwiimeko ezigqithisileyo
B. Iinzuzo zeflumazenil ekubuyiseni uthomalaliso olugqithisileyo
C. Iingxaki kunye nemingcipheko ehambelana nokusetyenziswa kwenkathalo ebukhali
D. Iingqwalasela zedosi ezininzi kunye nokubeka iliso ngononophelo

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III. Isicelo sasemva kotyando:

A. Ukuguqulwa kweempembelelo ze-sedative ze-benzodiazepines emva kokuhlinzwa

B. Ukufana nokusetyenziswa kwenaloxone ekuguqulweni kwe-opioid

C. Ukujongwa kwe-Anesthesiologist kunye neengqwalasela zasemva kotyando


IV. Unyango lwe-Non-Benzodiazepine Hypnotic Overdoses:

A. Ukusebenza kwe-flumazenil kunyango lwe-zolpidem, i-zaleplon, kunye ne-zopiclone overdoses


V. Ukusetyenziswa okunokwenzeka kwi-Hypersomnia kunye ne-Gastrointestinal Side Effects:

A. Ukuncitshiswa kokulala okugqithisileyo kwemini kwi-primary hypersomnias

B. Ukunciphisa iziphumo ebezingalindelekanga zesisu ezibangelwa lunyango lomhlaza

C. Ukukhuselwa kweeseli ze-intestinal stem ngexesha le-chemotherapy kunye nonyango lwe-radiation


VI. Ukubaluleka kokulungelelanisa i-GABAA ye-Receptor Inhibition:

A. Ukukhusela iiseli ze-intestinal stem emonakalweni we-DNA ngexesha le-radiotherapy

B. Ukuqinisekisa ukubulawa kweeseli zomhlaza akuchaphazeleki



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I-Flumazenil, i-GABAA ekhethiweyo ye-receptor antagonist, isebenza njenge-antidote exabisekileyo kwiimeko ze-benzodiazepine overdose, enika ukuthintela okukhuphisanayo kunye nokuguqulwa kwemiphumo ye-sedative. Izicelo zayo zandisa ukusetyenziswa emva kokuhlinzwa, unyango lwe-non-benzodiazepine hypnotic overdoses, kunye neenzuzo ezinokubakho kwi-hypersomnia kunye nemiphumo emibi yesisu. Ukubeka iliso ngononophelo kunye nokuqwalaselwa kwemingcipheko kubalulekile xa unikezela nge-flumazenil, ngakumbi kukhathalelo olubukhali kunye nezicwangciso zasemva kotyando. Uphando olongezelelweyo luyafuneka ukuphonononga amandla alo apheleleyo ekukhuseleni iiseli ze-stem zamathumbu ngexesha lonyango lomhlaza ngelixa kugcinwa ukusebenza komhlaza wokubulala iiseli.

Inkcazo

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