I-Memantine HCl 99% Ubunyulu bunyanga i-Alzheimer's Factory Supply
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I-Memantine hydrochloride, ephuhliswe nguMerz eJamani, lichiza elinoveli ekuqaleni elalijoliswe kunyango lwesifo sengqondo esiyingozi. Isebenza njenge-N-methyl-D-aspartate (NMDA) engakhuphisaniyo ye-receptor antagonist, ivimba i-NMDA receptors kunye nokunciphisa i-glutamate-induced hyperexcitability. Le ndlela ijolise ekuphuculeni umsebenzi wokuqonda, ukukhusela i-apoptosis, kunye nokuphucula imemori. I-Pethidine hydrochloride yavunywa yiKomiti yaseYurophu yeeMveliso zeMichiza yePatent (CPMP) yonyango lwe-Alzheimer's ephakathi ukuya kwi-2002. Uphononongo olongezelelweyo luye lwabonisa ukusebenza kwayo kwizigulane ezine-Alzheimer's mild to moderate.
I-Memantine hydrochloride, isithako esisebenzayo kwi-pethidine hydrochloride, i-moderate-affinity, non-competitive NMDA receptor antagonist. Nangona ukusetyenziswa kwayo okuphambili kunyango lwe-Alzheimer's disease, sele ifundwe ngokubanzi kwaye isetyenziselwa ezinye izifo ze-nervous system ezifana ne-epilepsy, migraines, kunye neemeko zengqondo ezibandakanya ukuphazamiseka kwe-bipolar kunye ne-schizophrenia. I-Dementia iseyeyona nto iphambili ekugxilwe kuyo ekusetyenzisweni kwe-memantine, kwaye ibonise amanqanaba ahlukeneyo oncedo kwi-Alzheimer's, isifo sengqondo esiyingozi kwi-vascular, kunye ne-dementia kunye nemizimba ye-Lewy. Ayiphuculi nje kuphela ukusebenza kwengqondo kodwa ikwajongana neempawu zokuziphatha kunye nezengqondo ze-dementia (BPSD), ezinje ngemibono, ukukhohlisa, ukuphazamiseka, ubundlongondlongo kunye nokucaphuka.
Ukongeza kwimpembelelo yayo kwi-dementia, i-memantine iphandiwe ngemiphumo yayo kwezinye izifo ze-neurological. Izigulana ezinesathuthwane zihlala zinengxaki yokuqonda, kwaye i-memantine ibonise amandla okunciphisa ezi ntsilelo. Ngaphezu koko, isifo sika-Alzheimer singumngcipheko wokuxhuzula, kwaye abantu abanesi sifo basengozini enkulu yokuxhuzula xa kuthelekiswa nabo bangenayo i-Alzheimer's. Ngokuthintela i-neuroexcitotoxicity ehambelana ne-NMDA receptor hyperactivation, i-memantine ingaba nemiphumo ye-antiepileptic.
Ngapha koko, i-memantine ifundwe kumxholo we-brain-brain radiation therapy (WBRT), ukulimala kwengqondo (TBI), kunye ne-stroke. I-WBRT inokukhokelela ekuphazamisekeni kwengqondo, kwaye i-memantine ibonakaliswe ukulibazisa ukuqala kwayo kunye nokuphucula ukusebenza kwengqondo. Iimpawu ezikhethekileyo ze-pharmacological ze-memantine ziye zakhokelela ekuhlolisweni kwayo kuluhlu olubanzi lweengxaki ze-neurological.
Uphononongo lwakutsha nje lude lwacebisa usetyenziso olunokubakho lwe-memantine ekudambiseni iziphumo ze-neurotoxic ze-COVID-19 kunye nokuthintela ukuphindaphinda kwentsholongwane, ebonisa ixabiso layo leklinikhi elandayo.
I-Memantine hydrochloride, ngokukodwa isithako sayo esisebenzayo i-memantine hydrochloride, ibonise ukusebenza kakuhle kunyango lwe-dementia, ngakumbi isifo se-Alzheimer. Indlela yayo ekhethekileyo njenge-NMDA ye-receptor antagonist ivumela ukuphuculwa komsebenzi wokuqonda kunye nokulawulwa kweempawu zokuziphatha kunye neengqondo ezinxulumene nesifo sengqondo. Ngaphezu koko, i-memantine ibonisa isithembiso kwezinye iziphazamiso ze-neurological ezifana nokuxhuzula, i-migraines, kunye ne-post-radiation cognitive impairment. Uphando oluqhubekayo luyaqhubeka nokuhlola ixabiso lekliniki elinokubakho le-memantine kwiimeko ezahlukeneyo ze-neurological.
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