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I-Tadalafil yi-crystalline powder emhlophe ukuya kumhlophe, ayinakunyibilika emanzini, ibonisa ukunyibilika okuncinci, kwaye i-soluble encinci kwi-alcohol.
Umsebenzi ophambili weTadalafil kukuphatha ukungasebenzi kakuhle kwe-erectile ngokunyusa ukuhamba kwegazi kwi-penis ngexesha lokuvuselela ngokwesondo.Ifezekisa oku ngokuthintela i-enzyme phosphodiesterase uhlobo lwe-5 (PDE5), olujongene nokuthotywa kwe-cyclic guanosine monophosphate (cGMP) kwi-corpus cavernosum. Ngokuthintela i-PDE5, i-tadalafil ivumela i-vasodilation ixesha elide kunye nokunyuka kwegazi, okunceda amadoda ane-erectile dysfunction ukuze afezekise kwaye agcine ukulungiswa. ukuya kwiiyure ezingama-36, uyifumana igama lesiqhulo "ipilisi yempelaveki."
I-Tadalafil iboniswa ikakhulu kunyango lwe-erectile dysfunction (ED) kumadoda amadala. Ifumaneka kwifom yethebhulethi yokulawulwa komlomo, kwiidosi ezivela kwi-2.5 mg ukuya kwi-20 mg, kuxhomekeke kwiimfuno zesigulane kunye nesimo esiphathwayo. I-dose yokuqala ekhuthazwayo kwizigulane ezininzi yi-10 mg, ethathwe ngaphambi komsebenzi wesondo olindelekileyo, kunye okanye ngaphandle kokutya. I-dose inokulungiswa ngokusekelwe kukunyamezela komntu ngamnye kunye nokuphendula.Ngaphezu kokusetyenziswa kwayo kwi-erectile dysfunction, i-tadalafil iphinda ivunywe unyango lweempawu kunye neempawu ze-benign prostatic hyperplasia (BPH), imeko ebonakaliswe yi-prostate gland. Xa i-BPH ihamba kunye nokungasebenzi kakuhle kwe-erectile, i-tadalafil inokubonelela ngenzuzo emibini ngokujongana neemeko zombini ngaxeshanye.
Ngapha koko, i-tadalafil isetyenziselwa ukulawula i-pulmonary arterial hypertension (PAH) kumadoda nabasetyhini. Kwesi sicelo, kunceda ekuphuculeni umthamo wokuzilolonga kunye nokulibazisa ukonakala kweklinikhi kwesi sifo.
Ukuqukumbela, i-tadalafil yi-white crystalline powder emhlophe ukuya kumhlophe kunye nokunyibilika okulinganiselweyo, eyona nto isetyenziselwa ukunyanga ukungasebenzi kakuhle kwe-erectile, i-benign prostatic hyperplasia, kunye noxinzelelo lwegazi lwe-pulmonary arterial. Njenge-PDE5 inhibitor, iququzelela ukunyuka kwegazi kwiindawo ezithile zomzimba, ngokukodwa i-penis, eyenza ukuphuculwa komsebenzi we-erectile. Ukongeza, ixesha layo elide lesenzo liyibeka yahluke kwamanye amayeza eklasini yawo, ibonelela ngokuguquguquka kunye nokuzenzekelayo kubantu abafuna unyango lwe-ED.
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