I-Triptorelin, i-decapeptide yokwenziwa kunye ne-analog ye-gonadotropin-ekhupha ihomoni yendalo (GnRH), ifumene ukuqondwa okubalulekileyo kwicandelo lezonyango. Isetyenziselwa imiqondiso eyahlukeneyo, kubandakanya unyango lwe-endometriosis, i-fibroids, umhlaza wedlala lesinyi, ukufikisa kwangaphambili, kunye nobudlolo. I-Triptorelin isebenza ngokuvuselela ukukhutshwa kwe-gonadotropins kwaye emva koko yehlise i-gonadotropin-ikhupha i-hormone receptors, ekhokelela ekunciphiseni kwexesha elide lokukhutshwa kwe-gonadotropin.
I-Triptorelin ibonisa uluhlu olubanzi lweziphumo zonyango. Kwabasetyhini, isetyenziselwa ukulawula i-endometriosis, i-uterine fibroids, kunye nokungazali. Ulawulo oluqhubekayo lwe-Triptorelin luthintela ngokufanelekileyo ukuveliswa kwe-estradiol, ekhokelela ekunyanzelweni kwezicubu ze-ectopic endometrial kwi-endometriosis. Ukongeza, izifundo zibonise ukuncipha okukhulu kubungakanani be-uterine fibroids, uninzi lwezigulane ezifumana i-amenorrhea emva kwenyanga yokuqala yonyango. Ngokungabikho komntwana, i-tritorelin inqanda ukukhutshwa kwe-gonadotropins, ukuphucula umgangatho wemveliso ye-follicle kunye nokwandisa inani leefollicles, ngaloo ndlela kwandisa amathuba obuchule obuncedisiweyo bokuzala obufana ne-in vitro fertilization.
Emadodeni, i-tritorelin isetyenziswa ngokuqhelekileyo kulawulo lomhlaza wesinyi. Isebenza ngokunyusa ihomoni ye-luteinizing (LH) kunye ne-follicle-stimulating hormone (FSH) kunye namanqanaba e-follicle-stimulating hormone (FSH), elandelwa kukuncipha kwezi hormone kunye nokuncipha okulandelayo kumanqanaba e-testosterone yegazi. Oku kuncipha kwamanqanaba e testosterone kunceda kunyango lomhlaza wedlala lesinyi kunye neempawu ezihambelana nazo. Iinaliti ze-Triptorelin zikwasebenza kunyango lokufikisa kwangaphambili, inqanda i-pituitary hypersecretion ye-gonadotropins kunye namanqanaba ehomoni aqhelekileyo.
Iindlela zokusebenza ze-triptorelin zibandakanya zombini ukucinezelwa kwe-gonadotropin secretion kunye ne-gonadotropic inhibition ethe ngqo ngokukhupha i-peripheral GnRH receptors. Izifundo zezilwanyana kunye nabantu zibonise iziphumo ezithintelwayo zokusetyenziswa kwe-tritorelin engapheliyo kwi-gonadotropin secretion, ekhokelela ekucutheni umsebenzi we-testicular kunye ne-ovarian. Ukusebenza kwe-Triptorelin kungqinwa ngakumbi kukuphucuka kwekliniki kwiimpawu ezinjenge-dysmenorrhea, iintlungu ezingapheliyo ze-pelvic, kunye neentlungu ngexesha lokwabelana ngesondo.
Sinikezela ngezisombululo ezahlukeneyo ezilungiselelwe wena ukuba ukhethe kuzo
Inaliti ye-Triptorelin: 0.1 mg / 1 ml.
I-Triptorelin yokukhupha i-injection eyongezelelweyo: 3.75 mg; 11.25 mg; 22.5 mg.
I-Triptorelin pamoate yenaliti: 15 mg ibhotile (iqulathe ibhotile ye-2 ml ye-solvent). Ukuba unezinye iimfuno, unokuqhagamshelana nathi kwaye siya kukunika iinkonzo ezikhawulezayo nezichanekileyo.
Njenge-analog ye-gonadotropin enamandla, i-Triptorelin ibonelela ngoluhlu lwezicelo zonyango kumadoda nabasetyhini. Ukukwazi kwayo ukulawula amanqanaba ehomoni kunye nokunqanda ukukhutshwa kwe-gonadotropin kungqineke kusebenza kakuhle ekulawuleni iimeko ezifana ne-endometriosis, i-uterine fibroids, umhlaza wesibeleko, ukufikisa kwangaphambili, kunye nokungazali. Ngokusebenza kwayo kweklinikhi kunye nokuguquguquka, i-tritorelin iyaqhubeka ifaka isandla kakhulu kwintsimi yeyeza lokuzala kunye ne-oncology.Ukuqonda iindlela zokwenza kunye namalungiselelo akhoyo e-tritorelin avumela abaqeqeshi bezempilo ukuba balungelelanise izicwangciso zonyango kwiimfuno zesigulane ngasinye.
