I-Vincristine Sulfate Powder I-Vincristine Purity Vincristine CAS 57-22-7
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IVincristine yicrystalline powder emhlophe ukuya kumhlophe. Ayinyibiliki emanzini, kodwa inyibilika kwezinye izinyibilikisi eziphilayo. Ikhompawundi ecocekileyo ayinavumba kwaye igcinwa kwindawo eyomileyo, emnyama phantsi kweemeko zobushushu ezilawulwayo ukuze kugcinwe uzinzo. Yindalo ye-alkaloid evela kwisityalo saseMadagascar i-periwinkle (Catharanthus roseus) .Isakhiwo sayo sekhemikhali sifana ne-vinblastine, enye i-vinca alkaloid.I-Vincristine isetyenziswa ngokubanzi kunyango lweentlobo ezahlukeneyo zomhlaza, kubandakanywa i-leukemia, i-lymphoma, kunye namathumba aqinileyo. .
I-Vincristine yi-microtubule inhibitor ephazamisa ukubunjwa kwee-microtubules, eziyinxalenye ebalulekileyo ye-cytoskeleton yeseli. Ngokuzibophelela kwi-tubulin, ikhusela ukuhlanganisana kwe-microtubules, ekhokelela ekubanjweni kwe-mitotic kunye nokufa kweeseli kwiiseli ezisebenzayo. I-vincristine isebenza ngokukodwa ngokuchasene neeseli zomhlaza ezahlula ngokukhawuleza.Izicelo zeClinical ze-vincristine ziquka unyango lwezifo ezahlukeneyo ezifana ne-acute lymphoblastic leukemia (ALL), i-Hodgkin's kunye ne-non-Hodgkin's lymphomas, i-lymphomas yabantwana kunye nabantu abadala, i-neuroblastoma, kunye ne-rhabdomyosarcoma.Vincristine isetyenziswa rhoqo. ngokudityaniswa nezinye ii-agent ze-chemotherapeutic njengenxalenye yerejimeni zonyango lweziyobisi ezininzi, ezaziwa ngokudibeneyo njenge-chemotherapy edibeneyo.
Ukongeza kusetyenziso lwayo oluphambili kunyango lomhlaza, ivincristine ikwabonakalise ukusebenza kakuhle kulawulo lweemeko ezithile ezingezizo eze-oncological. Isetyenziswa kunyango lwe-idiopathic thrombocytopenic purpura (ITP), ukuphazamiseka kwe-autoimmune okuphawulwa ngokubala kweplatelet ephantsi.Ngaphezu koko , i-vincristine ibonise amandla okulawula iimeko ezahlukeneyo ze-neurological, kubandakanywa ukuvuvukala okungapheliyo kwe-polyneuropathy (CIDP) kunye neengxaki ze-autoimmune neuropsychiatric zabantwana ezinxulumene nosulelo lwe-streptococcal (PANDAS).
Ngaphaya koko, iipropathi ze-vincristine ezichasene ne-angiogenic zikhokelele ekuphononongweni kokusetyenziswa kwayo okunokubakho kunyango lwezigulo ezahlukeneyo ezikhulayo, kubandakanywa i-retinopathy yesifo seswekile kunye ne-macular degeneration enxulumene nobudala. Nangona kunjalo, ivincristine yaziwa kakhulu ngendima yayo kunyango lomhlaza, kunye nokusetyenziswa kwayo ezinye iimeko zonyango zithathwa njenge-off-ileyibhile kwaye zifuna ukuphononongwa ngononophelo lweengozi kunye neenzuzo ezinokuthi zibekho.Ngokufutshane, i-vincristine, ephuma kwisityalo saseMadagascar i-periwinkle, i-agent anti-cancer exabisekileyo ephazamisa ukubunjwa kwe-microtubule kwaye ibangele ukufa kweeseli kwiiseli ezahlulayo. Izicelo zeklinikhi ezibanzi ziquka unyango lwe-leukemia, i-lymphoma, i-tumor eqinile, kunye neemeko ezithile ezingenayo i-oncological.Nangona ukusetyenziswa kwayo okuphambili kunyango lomhlaza, uphando oluqhubekayo luqhubeka nokuhlola amandla alo kwiimeko ezahlukeneyo zonyango.
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