I-Abaloparatide, imakethwa ngaphansi kwegama lomkhiqizo i-Tymlos, i-analog yokwenziwa ye-parathyroid hormone-related protein (PTHrP). Kuyi-agent ye-anabolic esetshenziselwa ukwelapha i-osteoporosis, isimo esibonakala ngamathambo abuthakathaka kanye nengozi eyengeziwe yokuphuka. I-Abaloparatide ikhonjiswe kwabesifazane be-postmenopausal nabesilisa abane-osteoporosis engozini enkulu yokuphuka, kanye nalabo abahlulekile noma abangabekezeleli ezinye izindlela zokwelapha ezitholakalayo ze-osteoporosis. Ngokukhetha ngokukhetha i-parathyroid hormone 1 receptor (PTH1R), i-abaloparatide ikhuthaza ukukhula kwamathambo futhi ikhulise ukuminyana kwamathambo.
I-Abaloparatide iyi-analogue yokwenziwa ye-amino acid engama-34 ye-PTHrP, ene-41% homology ku-hormone ye-parathyroid (PTH) (1-34) kanye ne-76% ye-homology ku-PTHrP (1-34). Indlela yayo yokusebenza ibandakanya ukubophezela ku-PTH1R, isamukeli se-G protein-coupled esivezwa kuma-osteoblasts nama-osteocyte. Ngokukhetha ngokukhethekileyo ukubophezela kusimo sokuvumelana kwe-RG se-PTH1R, i-abaloparatide iveza impendulo yesikhashana yomjikelezo we-AMP we-AMP, okuholela endleleni yokusayina ye-anabolic.
Kwabesifazane abangemva kokuya esikhathini abane-osteoporosis abasengozini enkulu yokuphuka, i-abaloparatide iyindlela yokwelapha esebenzayo. Kuyasiza ukwandisa isisindo samathambo futhi kunciphise ingozi yokuphuka. Ukwengeza, i-abaloparatide ingasetshenziswa ukukhulisa ukuminyana kwamathambo emadodeni ane-primary or hypogonadal osteoporosis asengozini enkulu yokuphuka noma ahlulekile noma angakwazi ukubekezelela ezinye izindlela zokwelapha ezitholakalayo.
Ngaphezu kwalokho, i-abaloparatide inikeza izinzuzo kubo bobabili abesilisa nabesifazane abane-osteoporosis ehambisana nokwelashwa okuqhubekayo kwe-glucocorticoid. Laba bantu basengozini enkulu yokuphuka ngenxa yokusebenzisa isikhathi eside ama-glucocorticoids. I-Abaloparatide ingasiza ukuthuthukisa amandla amathambo futhi inciphise ingozi yokuphuka kulesi sibalo esithile.
I-Abaloparatide, i-analogue yokwenziwa ye-PTHrP, iyindlela yokwelapha ebalulekile ye-osteoporosis. Izakhiwo zayo ze-anabolic zikhuthaza ukukhula kwamathambo futhi andise ukuminyana kwamathambo, ukunciphisa ingozi yokuphuka. Iboniswa kwabesifazane nabesilisa abangemva kokuya esikhathini abasengozini enkulu yokuphuka, kanye nakubantu abahlulekile noma abangabekezeleli ezinye izindlela zokwelapha ze-osteoporosis. Ngokusebenzisa i-PTH1R ngokukhetha, i-abaloparatide iqala indlela yokubonisa i-anabolic ethuthukisa impilo yamathambo. Ukusetshenziswa kwayo ku-osteoporosis ehambisana nokwelashwa okuqhubekayo kwe-glucocorticoid kunikeza inketho yokwelapha ebalulekile kubantu abasengozini enkulu yokuphuka. I-Abaloparatide idlala indima ebalulekile ekubhekaneni nezidingo zeziguli ezine-osteoporosis kanye nokwenza ngcono impilo yamathambo kanye nezinga lempilo.
