0102030405
I-Abarelix Enamandla I-Gonadotropin-Releasing Hormone Antagonist for Prostate Cancer Treatment
Incazelo Eningiliziwe
I-Abarelix, i-decapeptide yokwenziwa, ibonisa umsebenzi onamandla wokuphikisa ngokumelene nehomoni yemvelo ekhipha i-gonadotropin (GnRH). Ngokuyinhloko isetshenziselwa ukwelapha iziguli ezinomdlavuza we-prostate onezimpawu ezithuthukisiwe ezingezona ukhetho olufanele lwe-luteinizing hormone-releasing hormone agonists noma ukuthenwa ngokuhlinzwa. Ngokuvimbela ngokuqondile ukukhiqizwa kwehomoni ye-luteinizing (LH) kanye ne-follicle-stimulating hormone (FSH), i-abarelix inciphisa ngempumelelo ukukhiqizwa kwe-testosterone emasendeni. ake sihlole izinkomba zokwelapha, izindlela zesenzo, nokusetshenziswa kwe-abarelix.
I-Abarelix ikhonjiswe ekwelapheni kwe-palliative kweziguli ezinezimpawu ezinomdlavuza we-prostate osezingeni eliphakeme ezihlangabezana nemibandela ethile. Kunconywa ezigulini ezingafaneleki ukhetho lwe-luteinizing hormone-releasing hormone agonists, ukwenqaba ukuthenwa ngokuhlinzwa, futhi zibe nezici ezengeziwe zobungozi ezifana nokwenzeka kokulimala kwezinzwa ngenxa ye-metastasis, ureteral noma i-orifice yesinye okubangelwa ukuguguleka kwendawo noma i-metastasis, noma ubuhlungu obukhulu bethambo obuyi-metastatic obudinga ukukhululeka kobuhlungu obuqhubekayo.
Njengomphikisi omjova okhipha i-gonadotropin ekhipha i-hormone (umphikisi we-GnRH), i-abarelix idlala indima ebalulekile ekwehliseni ukukhiqizwa kwe-testosterone ezigulini ezinomdlavuza wendlala yesinye oyizimpawu ezithuthukile lapho ezinye izindlela zokwelapha zilinganiselwe. Ivimbela ngokuqondile ukukhishwa kwe-LH ne-FSH, okuthi kamuva inciphise ukukhululwa kwe-testosterone emasendeni. Ngokuncisha amangqamuzana omdlavuza wendlala yesinye i-testosterone, i-abarelix isiza ekulawulweni kwesifo nasekunciphiseni izimpawu ezihambisanayo.
Ukusetshenziswa kwe-abarelix ekwelapheni umdlavuza wendlala yesinye kunikeza enye indlela ebalulekile ezigulini ezingakwazi ukwenza noma ukwenqaba ukuthenwa ngokuhlinzwa noma ezinye izindlela zokwelapha ezingamahomoni. Ikhono layo lokuphikisa i-GnRH kanye nokucindezela ukukhiqizwa kwe-testosterone linikeza impumuzo yokudambisa futhi lisiza ukulawula ukuqhubeka kwesifo. Ngokunciphisa amazinga e-testosterone, i-abarelix isiza ekuvimbeleni ukukhula nokwanda kwamangqamuzana omdlavuza wendlala yesinye, ngaleyo ndlela inikeze ukukhululeka okuyizimpawu futhi ithuthukise izinga lempilo yesiguli.
U-Abarelix, umphikisi onamandla we-gonadotropin-ekhulula i-hormone, iyindlela yokwelapha ebalulekile ezigulini ezinomdlavuza wendlala yesinye oyizimpawu ezithuthukisiwe ezingafaneleki kuma-agonists akhipha i-hormone e-luteinizing noma ukuthenwa ngokuhlinzwa. Ngokuvimbela ngokuqondile ukukhiqizwa kwe-LH ne-FSH, i-abarelix inciphisa ngempumelelo ukukhiqizwa kwe-testosterone, okubalulekile ekukhuleni nasekuqhubekeleni phambili komdlavuza wendlala yesinye. Ukusetshenziswa kwayo kunikeza impumuzo yokudambisa futhi kusiza ukuphatha lesi sifo ezigulini ezinezinketho zokwelashwa ezilinganiselwe. I-Abarelix, imakethwa njenge-Plenaxis, isebenza njengethuluzi elibalulekile ekulweni nomdlavuza we-prostate othuthukisiwe, onikela ekuthuthukisweni kwemiphumela yesiguli kanye nezinga lempilo elithuthukisiwe.
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