I-Arecoline hydrobromide Therapeutic Potential ohlelweni lwezinzwa olumaphakathi

Intengo Yereferensi: USD15-20/g

Igama Lomkhiqizo I-Arecoline
Inombolo ye-CAS. 300-08-3
MF I-C8H14BrNO2
MW 236.109
EINECS 206-087-3
I-acidity coefficient (pka) 6.84(ku-25℃)
Iphoyinti lokuncibilika 171-175°C

Xhumana nathi

imininingwane yomkhiqizo

Incazelo Eningiliziwe

I-Arecoline, i-alkaloid eyinhloko esebenzayo etholakala kuntongomane ye-areca, isithole ukunakwa ngamandla ayo okwelapha ekubhekaneni nokuphazamiseka kwengqondo kanye nokunciphisa ukugula kwesisu. Lesi sihloko sihlose ukunikeza isifinyezo esihlelekile sendlela yokusebenza ye-arecoline ezinhlelweni ezihlukahlukene zomzimba, okuhlanganisa i-oral cavity, isimiso sezinzwa esimaphakathi, isimiso senhliziyo nemithambo yegazi, kanye nesistimu yokugaya ukudla. Ukwengeza, imisebenzi yezempilo kanye nemiphumela enobuthi engaba khona ye-arecoline izohlolwa. Ekugcineni, ukusetshenziswa kwe-arecoline ezithanjeni zokudla kwezempilo, imithi, namalungiselelo ezimonyo kuzoxoxwa ngakho.

I-Arecoline, i-nicotinic acid-based mild parasympathomimetic stimulant alkaloid, isebenza ngokuyinhloko njengengxenye ye-agonist ye-muscarinic acetylcholine receptors. Ibonisa imiphumela ye-parasympathetic esikhundleni se-nicotinic acetylcholine receptors ebuhlungu njenge-nicotine. I-Arecoline iphinde ivimbele i-AMPK (i-adenosine monophosphate-activated protein kinase) ngokukhiqizwa kwezinhlobo ze-oxygen esebenzayo (ROS) ezinhlotsheni zamaseli ezihlukahlukene.

Imithelela Kumasistimu Omzimba Ahlukene:

Isistimu Yezinzwa: I-Arecoline ikhuthaza ukujabula, ithuthukisa ukufunda nenkumbulo, futhi yehlisa izimpawu zokucindezeleka kanye nengqondo. Ingase futhi ihlehlise ukulahleka kwenkumbulo okubangelwa i-scopolamine.

I-Cardiovascular System: I-Arecoline isebenza njenge-vasodilator, ikhulisa i-plasma nitric oxide, i-eNos, ne-mRNA expression, futhi ibonisa i-anti-thrombosis kanye nemiphumela yokulwa ne-atherogenic. Iphinde yehlise i-IL-8 nezinye izici.

I-Endocrine System: I-Arecoline ivuselela amaseli e-Leydig, okuholela ekwandeni kwamazinga e-testosterone. Ivula i-axis ye-hypothalamic-pituitary-adrenal (HPA), ikhuthaze ukukhululwa kwe-corticotropin-releasing hormone (CRH). Ukwengeza, kusiza ukuvimbela ukungasebenzi kwamaseli we-pancreatic beta okubangelwa ukudla okuphezulu kwe-fructose.

I-Digestive System: I-Arecoline ivuselela uhlelo lokugaya ngokusebenza kwama-muscarinic receptors. Yandisa ukufinyela kwemisipha ebushelelezi yesisu kanye nemicu yemisipha ye-duodenum, ileum, nekholoni.

Imisebenzi Yezempilo Nezicelo:

I-Analgesia kanye Nemiphumela Yesistimu Yezinzwa Emaphakathi: I-Arecoline hydrobromide ibonisa izakhiwo ze-analgesic futhi inomphumela wokuzinza ohlelweni lwezinzwa oluphakathi.

Impilo Yesikhumba: I-Arecoline hydrobromide ikhuthaza umzimba wesikhumba futhi ikhombisa amandla okwelapha izilonda zesikhumba nezinye izifo zesikhumba.

I-Detoxification kanye ne-Diuretic Effects: I-Arecoline hydrobromide isusa ukushisa, ikhiphe ubuthi, iqede ubumanzi nokuvuvukala, futhi inezindawo zokukhipha isisu.

I-Antibacterial and Dissolving Stones: I-Arecoline hydrobromide ikhombisa izakhiwo ezilwa namagciwane kanye nekhono lokuncibilikisa amatshe.

Ukuqinisa Imithambo Yegazi Nokujikeleza Kwegazi: I-Arecoline hydrobromide isiza ukuqinisa imithambo yegazi futhi ikhuthaze ukujikeleza kwegazi.

Izicelo:

I-Health Food Supplements: I-Arecoline ingasetshenziswa njengesithako sezithako zokudla kwezempilo eziqondise imisebenzi ethile yezempilo, njengokuthuthukisa ingqondo noma impilo yesikhumba.

Imithi: I-Arecoline ingase ibe nezicelo ezingase zibe khona kwezokwelapha, ikakhulukazi ekwelapheni ukuphazamiseka kwengqondo noma njengesidakamizwa se-antihelmintic.

Ukulungiselela Izimonyo: Ukugqugquzelwa kwe-Arecoline's skin metabolism kanye nezindawo zokupholisa amanxeba ezingaba khona kuyenza ibe ikhandidethi yamalungiselelo ezimonyo, ikakhulukazi lawo aqondise izilonda zesikhumba noma ezinye izifo ezihlobene nesikhumba.

I-Arecoline, i-alkaloid esebenzayo etholakala kuntongomane ye-areca, ibonisa imiphumela ehlukahlukene yokwelapha futhi isetshenziswa ezinhlelweni ezihlukene zomzimba. Izindlela zayo zokwenza ngokuyinhloko ziqondiswa ngama-muscarinic receptors futhi zibonisa imiphumela ye-parasympathetic. Nakuba i-arecoline ibonisa isithembiso ekubhekaneni nezimo ezithile zezempilo, kubalulekile ukucabangela imiphumela engase ibe nobuthi kanye nezakhiwo ze-carcinogenic ezihlobene nokusetshenziswa kwayo.Xhumana nathi uma udinga.

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