Ukuzalwa ngaphambi kwesikhathi kudala izingozi ezinkulu kanye nemithwalo kuyo yomibili imindeni kanye nomphakathi uwonke. Ngenxa yalokho, ukuvimbela nokwelashwa kokuzalwa ngaphambi kwesikhathi kubaluleke kakhulu. Ama-tocolytics, afana ne-atosiban, adlala indima ebalulekile ekubambezeleni ukusikwa ngaphambi kwesikhathi nokuvikela umbungu. I-Atosiban, i-cyclic nonapeptide kanye ne-oxytocin analogue, isebenza njengomphikisi oqhudelanayo wama-oxytocin receptors esibelethweni, i-decidua, kanye nolwelwesi lwengane. Ngokuvimbela ukufinyela kwesibeletho, i-atosiban iye yavela njengethuluzi lomtholampilo elibalulekile ekwelapheni ukuzalwa ngaphambi kwesikhathi.
I-Atosiban, njenge-oxytocin ehlanganisiwe ne-vasopressin V1A receptor antagonist, inikeza indlela eyingqayizivele yokuvimbela ukufinyela kwesibeletho. Ukufana kwesakhiwo phakathi kwesamukeli se-oxytocin nesamukeli se-vasopressin V1A sidinga ukuvinjwa ngasikhathi sinye kwazo zombili izindlela zokwamukela ukuze kuvinjwe ngempumelelo ukufinyela kwesibeletho. Ngokungafani namanye ama-tocolytics afana nama-beta-agonists, ama-calcium channel blockers, nama-prostaglandin synthase inhibitors, ukuphikiswa okukabili kwama-atosiban receptor kuvumela ukuvinjwa okuphumelelayo kokufinyela kwesibeletho. I-Oxytocin, ngaphezu kokuvuselela ukufinyela kwesibeletho, iphinde ikhuthaze ukukhiqizwa nokukhululwa kwe-PGF2α, okubuye kube nomthelela ekufinyezweni kwemisipha ebushelelezi yesibeletho. Ukuhlobana okuphezulu kwe-Atosiban kwe-oxytocin nama-vasopressin V1A receptors kubophezela ngokuncintisana kulawa ma-receptor, kuvimbe ngempumelelo izindlela zesenzo se-oxytocin ne-vasopressin. Lo mshini uholela ekunciphiseni ukufinyela kwesibeletho.
Enye yezinzuzo ezibalulekile ze-atosiban yimiphumela yayo emibi emincane. Nakuba kuye kwabikwa ukuthi i-tachycardia ethambile, ukucinana kwesifuba, isiyezi, ikhanda elibuhlungu, isicanucanu, nokuphefumula kanzima kuye kwabikwa, le miphumela engemihle ngokuvamile ayidingi ukwelashwa okukhethekile, futhi isidakamizwa asivamile ukuyekwa ngenxa yemiphumela engemihle. Ngaphezu kwalokho, i-atosiban inohafu wokuphila kwe-plasma emfushane, ikhawulela ukunqwabelana kwayo ekujikelezeni kwengane futhi inciphisa ingozi yemiphumela emibi ku-fetus.Ukuhlolwa komtholampilo kubonise ukusebenza kahle kwe-atosiban ekwandiseni isikhathi sokukhulelwa kwabesifazane abanamaviki angaphezu kwangu-28 okukhulelwa. Esivivinyweni se-multicenter, esingaboni kabili, esilawulwa yi-placebo, ukwelashwa kwe-atosiban kuholele ekwandiseni isikhathi sokukhulelwa kuze kufike ezinsukwini eziyi-7. Ukuhlolwa komtholampilo okuqhathanisayo kuphinde kwabonisa ukuthi i-atosiban inesenzo se-tocolytic esiqhathaniseka ne-ritodrine kuyilapho ibekezelelwa kangcono, ikakhulukazi ngokwemiphumela emibi yenhliziyo kamama. Lokhu okutholakele kugqamisa amandla e-atosiban njenge-ejenti ye-tocolytic esebenzayo nebekezelelwa kahle.
I-Atosiban, njengomphikisi oqhudelanayo wamamukeli we-vasopressin/oxytocin, idlala indima ebalulekile ekuvimbeleni ukuzalwa ngaphambi kwesikhathi. Ikhono layo lokuvimbela ukufinyela kwesibeletho ngokuphikisana kwama-receptor amabili kuyenza ibe ithuluzi elibalulekile lokubambezela ukusikwa ngaphambi kwesikhathi. Imiphumela engemihle emincane, uhhafu wempilo ye-plasma, kanye nokunqwabelana okulinganiselwe ekuhambeni kombungu kuqhubezela phambili ukuthuthukisa iphrofayili yayo yokuphepha. Ukwengeza, amandla e-atosiban ekuthuthukiseni imiphumela yokukhulelwa ezigulini ezinokwehluleka ukufakelwa okuphindaphindiwe ezithola i-IVF-ET abonisa ukuguquguquka kwayo kanye namandla ayo emithini yokuzala. Ucwaningo oluqhubekayo kanye nokusetshenziswa komtholampilo kwe-atosiban kungaba negalelo elikhulu ekwehliseni umthwalo wokuzalwa ngaphambi kwesikhathi emindenini nasemphakathini.
