0102030405
I-CARBETOCIN I-Postpartum Hemorrhage powder
Incazelo Eningiliziwe
Isingeniso:
I-Carbetocin, i-analog ye-oxytocin esebenza isikhathi eside yokwenziwa, ibonisa izici ezifana ne-oxytocin eyenzeka ngokwemvelo. Isebenza njenge-agonist, ibophezela kuma-receptors emisipha ebushelelezi kwesibeletho futhi ibangele ukufinyela okunesigqi kwesibeletho. I-Carbetocin isebenza ngokuyinhloko ezibelethweni ezikhulelwe nezisanda kuzalwa, njengoba okuqukethwe kwe-oxytocin receptor kuphezulu kakhulu ngalezi zikhathi. Kulesi sihloko, sizohlola izici zomtholampilo nezokwelapha ze-carbetocin, sigxile ekusetshenzisweni kwayo ekulawuleni ukopha kwangemva kokubeletha kanye nokuvimbela ukufinyela kwesibeletho ngemva kwesigaba sokuhlinzwa.
Ukulawulwa Kokopha Kwangemva Kokubeletha:
I-Carbetocin umuthi obalulekile osetshenziselwa ukulawula ukopha kwangemva kokubeletha, okubhekisela ekopheni okukhulu ngemva kokubeletha. Ngokwenza ukufinyela kwesibeletho, i-carbetocin isiza ukubuyisela ithoni yesibeletho, inciphisa ingozi yokopha ngokweqile. Ukusebenza kwayo kulele emandleni ayo okwandisa imvamisa nokushuba kokufinyela kwesibeletho, ukuvimbela noma ukunciphisa ukopha kwangemva kokubeletha.
I-Carbetocin ivame ukulawulwa ngemva kokukhetha i-epidural noma i-spinal anesthesia ngesikhathi sokuhlinzwa ukuze kuvinjelwe ukufinyela kwesibeletho kanye nokopha okwalandela ngemva kokubeletha. Lo mkhuba uqinisekisa ukuthi imisipha yesibeletho ihlala inkontileka, inciphisa amathuba okopha ngokweqile. Kodwa-ke, ukusetshenziswa kwe-carbetocin ezigabeni eziphuthumayo zokuhlinzwa, izigaba zokuhlinzwa zakudala, nangaphansi kwezinye izinhlobo ze-anesthesia noma lapho kunezimo ezithile zezokwelapha akuzange kufundwe kabanzi. Ngakho-ke, ukuqapha kufanele kusetshenziswe lapho kucatshangelwa ukuphathwa kwe-carbetocin kulezi zimo.
Indlela Yesenzo:
I-Carbetocin isebenza njengesidakamizwa i-oxytocic, i-antihemorrhagic, ne-uterotonic, ngokuyinhloko eqondise ohlelweni lwezinzwa lwe-peripheral. Isebenza njenge-agonist kuma-peripheral oxytocin receptors, ikakhulukazi ku-myometrium (umsipha wesibeletho). Lawa ma-oxytocin receptors angama-G protein-coupled, futhi ukusebenza kwawo kuhilela izithunywa zesibili kanye nokukhiqizwa kwe-inositol phosphates. I-Carbetocin ilingisa lo mshini, ibophezela ngokungakhethi ku-N-terminus engaphandle kanye namalophu E2 kanye ne-E3 ye-oxytocin receptor. Nakuba i-carbetocin ne-oxytocin inokuhlobana okufanayo kwama-receptors, umphumela webhayoloji we-carbetocin ucishe ube ngu-50% we-oxytocin engapheli noma engaphandle. Ngokuphawulekayo, i-carbetocin inomphumela ohlala isikhathi eside kune-oxytocin, edinga umthamo owodwa kuphela. Iphinde ivimbele ukukhishwa kwe-oxytocin engapheli, iphazamise iluphu yempendulo yesibeletho ne-hypothalamus futhi yehlise kokubili ukukhishwa kwe-oxytocin emaphakathi ne-peripheral. I-Carbetocin ingabhekwa njenge-agonist echemile ye-oxytocin receptor.
Ngesikhathi sokukhulelwa, ukwakheka kwama-oxytocin receptors esibelethweni kwanda kakhulu, kufinyelele umvuthwandaba ngesikhathi sokubeletha nokubeletha. Ngakho-ke, ukuphathwa kwe-carbetocin noma amanye ama-analogues e-oxytocin phakathi noma ngokushesha ngemva kokuzalwa kuthuthukisa imiphumela ye-uterotonic ne-contractile. Nokho, i-carbetocin ayinawo umthelela ezibelethweni ezingakhulelwe ezine-oxytocin receptor expression. Ukwengeza, i-carbetocin inomthelela ekuqinisweni kwegazi, iphinde inciphise ingozi yokopha kwangemva kokubeletha.
Izinyathelo zokuqapha kanye nemikhawulo:
Kubalulekile ukuqaphela ukuthi i-carbetocin akufanele isetshenziselwe ukwethulwa kokubeletha noma ukukhulisa, njengoba ingase iholele ekucindezelekeni kwenhliziyo noma ukuphefumula kumama nosana.
Isiphetho:
I-Carbetocin, i-synthetic oxytocin analog, inikeza indlela ebalulekile yokulawula ukopha kwangemva kokubeletha kanye nokuvimbela ukopha kakhulu ngemva kokuhlinzwa. Ngokulingisa izindlela ze-oxytocin eyenzeka ngokwemvelo, i-carbetocin idala ukufinyela kwesibeletho futhi ikhuthaze ithoni yesibeletho. Kodwa-ke, ukusetshenziswa kwayo kufanele kubhekwe ngokucophelela ezimeni ezithile, futhi ochwepheshe bezokunakekelwa kwempilo kufanele baqaphele lapho benikeza i-carbetocin.
Khumbula ukuthintana nathi ukuze uthole intengo eqondile yeCarbetocin Factory.
Ukucaciswa
