Imikhiqizo Izigaba

Imikhiqizo efakiwe

Amathebulethi eLenopril Anika Amandla Ukulawula Umfutho Wegazi kanye Nempilo Yenhliziyo

I-Telmisartan I-antihypertensive Protecting renal engcono

I-Flumazenil I-GABAA Receptor Antagonist ekhethiwe kanye nezicelo zayo zokwelapha

I-Trametinib Kinase Inhibitor Targeting BRAF V600 Mutation-Positive Cancers

I-Dabrafenib I-Targeted Therapy ye-BRAF-Mutated Cancers

I-Tirzepatide Dual GLP-1 kanye ne-GIP Receptor Agonist for Weight Management and Glycemic Control

I-Cisapride Gastric Stimulant for Indigestion and Digestive Disorders

I-YK-11 I-SARM Enamandla Yokwakhiwa Kwemisipha, Ukuzuza Amandla, kanye Ne-Myostatin Inhibition

I-Ostarine (MK-2866) I-SARM Eguquguqukayo Yokukhula Kwemisipha, Ukulahlekelwa Kwamafutha, Nokubuyiswa Komzimba

I-MK-677 Inhlanganisela Eyingqayizivele Yokukhula Kwemisipha, Ukukhuthazela, Nokubuyiselwa

I-Cisplatin Powder Cisplatin Purity 99% I-Cisplatin Pharmaceutical

I-Cisplatin Powder Cisplatin Purity 99% I-Cisplatin Pharmaceutical

Igama Lomkhiqizo Cisplatin
Ukubukeka Impushana ecwebezelayo ewolintshi-ophuzi ukuya kokuphuzi okumnyama
Inombolo ye-CAS. 15663-27-1
I-Chemical Formula I-Cl2H6N2Pt
Isisindo samangqamuzana 300.05
Iphoyinti lokuncibilika 270℃
Ukuminyana 3.7

Xhumana nathi

imininingwane yomkhiqizo

Incazelo Eningiliziwe

I-Cisplatin, eyaziwa nangokuthi i-Platinol, umuthi we-chemotherapy osetshenziselwa ukwelapha izinhlobo ezahlukene zomdlavuza.

Ukubukeka: I-Cisplatin iyimpushana ecwebezelayo emhlophe kuya kokumhlophe enephunga elibi. Incibilika kancane emanzini kodwa incibilika ezixazululweni ezine-chloride nezinye izincibilikisi eziphilayo. Inhlanganisela ehlanzekile imvamisa igcinwa endaweni eyomile, emnyama ngaphansi kokulawulwa. Izimo zokushisa ukuze kugcinwe ukuzinza kwayo.Lapho igcinwe kahle, i-cisplatin igcina ubuqotho bayo bamakhemikhali namandla.Yaqala ukuhlanganiswa ngo-1844 ngu-Alfred Werner, usokhemisi waseSwitzerland owathola uMklomelo KaNobel kuKhemistry ngo-1913 ngomsebenzi wakhe wokuhlanganisa ama-compounds. kamuva yaphenywa ngezindawo zayo zokulwa nomdlavuza ezingase zibe khona futhi kwatholakala ukuthi iyasebenza ekwelapheni izifo ezihlukahlukene.

Umsebenzi Nezicelo: I-Cisplatin ihlukaniswa njengomuthi we-chemotherapy osekelwe ku-platinum futhi iyingxenye yomndeni wama-alkylating agents.Isebenzisa imiphumela yayo yokulwa nomdlavuza ngokwenza izibopho ezihlangene ne-DNA, okuholela ekuphazamisekeni kokusebenza kwamaselula futhi ekugcineni kubangele ukufa kweseli. ,i-cisplatin ibophezela ezisekelweni ze-purine ku-DNA, yenza i-intrastrand kanye ne-interstrand crosslinks.Lawa ma-crosslink aphazamisa ukuphindaphinda kwe-DNA nokubhala, okuholela ekuvimbeleni ukwanda kwamangqamuzana kanye nokufakwa kwe-apoptosis kumaseli omdlavuza.I-Cisplatin isetshenziswa kabanzi ekwelapheni izinhlobonhlobo ezihlukahlukene izinhlobo zomdlavuza, okuhlanganisa umdlavuza wamasende, wesibeletho, esinyeni, ikhanda nentamo, umdlavuza wamaphaphu nowomlomo wesibeletho.

Ivamise ukuba yingxenye yenhlanganisela yemithi yokwelapha ngamakhemikhali futhi iphathwa ngomthambo esimeni somtholampilo ngaphansi kokugadwa ochwepheshe bezempilo. Inhlanganisela ye-cisplatin namanye ama-ejenti e-chemotherapeutic, njenge-etoposide, i-bleomycin, ne-fluorouracil, ibonise imiphumela ye-synergistic ekwelapheni okuthile. Ngaphezu kwendima yayo eyinhloko ekwelashweni okuqinile kwesimila, i-cisplatin iphinde isetshenziselwe ekwelapheni izimila zamangqamuzana amagciwane, kokubili njenge-ejenti eyodwa futhi lihlanganiswe neminye imithi yokwelapha ngamakhemikhali. ikakhulukazi uma isetshenziswa kanye nezinye izinto ezisekelwe ku-platinum njenge-etoposide ne-bleomycin. Ngaphezu kwalokho, i-cisplatin iye yacwaningwa ukuze isetshenziswe kwezinye izinhlobo zomdlavuza, okuhlanganisa nomdlavuza womminzo, wesisu, nowe-pancreatic.

Ucwaningo luyaqhubeka nokuhlola ukusebenza kahle kwalo ngokuhambisana nemithi yokwelapha ehlosiwe enoveli kanye nama-immunotherapies ukuthuthukisa imiphumela yokwelashwa nokunciphisa ukukhula kokungazweli. umzimba ukubulala amaseli omdlavuza noma ukuwenza azwele kakhulu kwezinye izindlela zokwelapha. Kulo mongo, i-cisplatin isetshenziswa ngokuhambisana nokushisa ukuze kuthuthukiswe imiphumela yayo ye-cytotoxic ngaphakathi kwe-tumor microenvironment.

Kafushane, i-cisplatin iyisidakamizwa sokwenziwa kwe-chemotherapy esekwe kwiplatinamu esinemiphumela yaso yokulwa nomdlavuza ngokwenza i-DNA crosslinks futhi ibangele ukufa kwamaseli kumangqamuzana omdlavuza. umdlavuza womlomo wesibeletho, ngocwaningo oluqhubekayo oluhlola amandla ayo kwezinye izifo ezibulalayo.Ukwengeza, i-cisplatin ingasebenza ekwelashweni kwe-hyperthermia futhi iyaqhubeka nokuba yingxenye ebalulekile yemithi ehlanganisiwe yokwelapha ngamakhemikhali.

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