Incazelo Eningiliziwe
I-Clomiphene, umuthi ogunyazwe i-FDA ngokuyinhloko osetshenziselwa izinkinga zokuzala kwabesifazane, ngokwesiko uthathwa njengongabafanele amadoda. Kodwa-ke, odokotela abasezingeni eliphezulu bathole ukusetshenziswa okungenzeka kwe-clomiphene emadodeni anezibalo eziphansi zesidoda ezibangelwa izici zofuzo noma ukusetshenziswa kwe-steroid. Ukwengeza, abakhi bomzimba besilisa sebeqalile ukusebenzisa i-clomiphene njengesidakamizwa sokugcina i-testosterone ukuze kuthuthukiswe ukuthuthukiswa kwemisipha. Sihlinzeka ngesifinyezo sendlela yokusebenza ye-clomiphene, imiphumela yayo emazingeni amahomoni, kanye nezinzuzo zayo ezingaba khona nobungozi kwabesilisa.
I-Clomiphene yaziwa ngokuthinta i-axis ye-estrogen emzimbeni, nakuba indlela yayo yokusebenza ihlala ingaqondakali. Isebenzisana nama-estrogen receptors ezicutshini ezihlukahlukene, okuhlanganisa i-hypothalamus, i-pituitary gland, ama-ovaries, i-endometrium, i-vagin, umlomo wesibeletho, izindlala ze-adrenal, izicubu ze-adipose ezizungezile, isibindi, namasende. Kwabesifazane, i-clomiphene ngokuyinhloko isebenza ku-hypothalamus kanye nendlala ye-pituitary, ivuselela ukukhiqizwa kwehomoni ekhipha i-gonadotropin (GnRH), i-follicle-stimulating hormone (FSH), ne-luteinizing hormone (LH). Lokhu kuvuselela kuthuthukisa i-ovulation. Kwabesilisa, i-clomiphene iphinde isebenze ku-hypothalamus kanye ne-pituitary gland, okuholela ekwandeni kokukhiqizwa kwe-testosterone nesidoda.
Ngokuphambene nenkolelo evamile, i-clomiphene ayinciphisi amazinga e-estrogen emzimbeni. Eqinisweni, kungase kukhuthaze ukukhiqizwa kwe-estrogen ngezinga elithile emadodeni. Kubalulekile kubantu abasebenzisa i-clomiphene, ikakhulukazi abakhi bomzimba besilisa, ukuqapha kokubili amazinga e-testosterone kanye ne-estradiol ukuze bagweme imiphumela engase ibe khona njenge-gynecomastia (ukukhulisa isifuba sowesilisa).
Abakhi bomzimba besilisa bavame ukusebenzisa i-clomiphene njenge-adjunct emijikelezweni yabo ye-steroid. Kodwa-ke, kubalulekile ukuqaphela ukuthi i-clomiphene ayihlukaniswa njengesidakamizwa esithuthukisa ukuzivocavoca futhi ayinayo imiphumela ye-androgenic. Ukusetshenziswa isikhathi eside kwe-clomiphene emadodeni kuye kwahlotshaniswa ne-macromastia (amabele akhulisiwe) kanye nezimila ze-testicular, nakuba isixhumanisi esiqondile esiyimbangela phakathi kwe-clomiphene nale miphumela emibi ayizange isungulwe.
Nakuba i-clomiphene isetshenziswa kakhulu ngabakhi bomzimba besilisa nabasubathi, ukusebenza kwayo emadodeni kuhlala kungaqiniseki ngenxa yezifundo ezilinganiselwe. Kubalulekile ukuqapha lapho ucubungula ukusetshenziswa kwe-clomiphene, ikakhulukazi lapho bungekho ubufakazi obuphelele. Ngaphezu kwalokho, kuyatuseka ukuthintana nochwepheshe bezempilo ngaphambi kokufaka i-clomiphene ohlelweni lwe-steroid.
Izincomo:
owesilisa
I-Clomiphene isetshenziswa ku-pct, kumthamo we-50-100 mg nsuku zonke ngezinsuku ze-30 ukubuyisela ukukhiqizwa kwe-testosterone yemvelo kumazinga avamile. Lokhu kusetshenziswa ngokuvamile kuthathwa njengokufaneleka kakhulu njengengxenye yohlelo lokubuyisela emuva komjikelezo (bona Ukwelashwa kwe-PCT)
abasubathi besifazane
I-Clomid ngezikhathi ezithile isetshenziselwa ukunciphisa i-estrogen ngaphambi kokuncintisana emncintiswaneni wokwakha umzimba. Kwezinye izimo, lokhu kungase kusize ukuncipha kwamafutha futhi kukhuthaze ukukhula kwemisipha, ikakhulukazi ezindaweni ezinezinkinga zabesifazane njengezinqe namathanga. Kodwa-ke, lesi sidakamizwa sivame ukuba nemiphumela emibi ekhathazayo kakhulu kwabesifazane abangaphambi kokuya esikhathini ngakho-ke asikho isidingo esikhulu phakathi kwaleli qembu.
I-Clomiphene, esetshenziswa ngokuyinhloko ezinkingeni zokuzala kwabesifazane, isithole ukunakwa ngokusetshenziswa kwayo emadodeni anezibalo eziphansi zesidoda futhi njengomuthi wokunakekela i-testosterone wabakhi bomzimba besilisa. Indlela yayo yokusebenza ibandakanya ukugqugquzela ukukhiqizwa kwe-gonadotropin, okubuye kukhuthaze ukuvuthwa kweqanda kwabesifazane nokukhiqizwa kwe-testosterone emadodeni. Kodwa-ke, ukuphumelela nokuphepha kwe-clomiphene emadodeni kudinga ucwaningo olwengeziwe.
Khumbula ukuxhumana nathi ukuze ulethelwe ngokushesha!
Ukucaciswa
