I-Eledoisin Acetate, ilungu lomndeni we-tachykinin, iyi-peptide esebenzayo enemiphumela ehlukahlukene yomzimba. Isebenza njenge-vasodilator enamandla kanye ne-secretagogue, yenza izenzo zayo emisipha ebushelelezi. I-Eledoisin Acetate ikhombisa ngokuyinhloko i-angiotensin II vasoconstriction futhi inyusa umfutho wegazi. Indlela yayo ihlanganisa ukufinyela kwemisipha ebushelelezi ye-arteriolar, ukwanda kokumelana ne-peripheral, ukukhululwa kwe-adrenal aldosterone eholela ekugcinweni kwe-sodium kanye nokwanda kwevolumu yegazi, umnikelo oqondile ku-renal tubular sodium ne-reabsorption yamanzi, kanye nokukhuthazwa komsebenzi we-vasoconstrictor ozwelayo ebuchosheni, okuholela ekwandeni kwemithambo ye-peripheral. ukumelana.
I-Eledoisin Acetate nayo inezakhiwo ze-antihypertensive. Ifinyelela lokhu ngokuvimbela iziteshi ze-calcium, ikakhulukazi iziteshi ze-calcium zohlobo lwe-L kumaseli we-coronary kanye ne-peripheral vascular smooth muscle. Ngokuvimbela ngokukhetha ukungena kwama-calcium ion kumaseli, i-eledoisin iphumuza amangqamuzana emisipha abushelelezi emithambo yegazi, okuholela ekwandeni kwemithambo yegazi ejikelezayo, kuncishiswe ukumelana ne-peripheral, futhi ekugcineni nokuncipha komfutho wegazi.
Ngaphezu komphumela wayo we-antihypertensive, i-eledoisin inikeza izinzuzo ze-cardioprotective. Ngokunciphisa umthwalo enhliziyweni nokunciphisa ukusetshenziswa komoya-mpilo wenhliziyo, kusiza ukuthuthukisa ukugeleza kwegazi kwe-coronary, kuthuthukise ukutholakala komoyampilo we-myocardial, futhi kunciphise izimpawu ze-angina pectoris.I-Eledoisin ivame ukusetshenziselwa ukwelapha umfutho wegazi ophakeme noma wesibili. Ingasetshenziswa yodwa noma ihlanganiswe neminye imithi ye-antihypertensive ukulawula ngempumelelo umfutho wegazi. I-Angina Pectoris ezinzile: Iziguli ezine-angina pectoris ezinzile ezibangelwa isifo senhliziyo zingazuza ekwelashweni kwe-eledoisin. Kuyasiza ekudambiseni izimpawu ezinjengokucinana kwesifuba nobuhlungu besifuba, kunikeze impumuzo kanye nokwenza ngcono impilo yonke yenhliziyo nemithambo yegazi.Ezimweni ze-acute coronary syndrome, i-eledoisin ingase ibhekwe njengokuthuthukisa isimo senhliziyo yesiguli, inikeze ukusekela kanye nokunciphisa ingozi yezinkinga.
I-Eledoisin Acetate, i-peptide eguquguqukayo, ibonisa imiphumela ehlukahlukene yomzimba, okuhlanganisa i-vasodilation, umsebenzi we-secretagogue, nokuguqulwa kwemisipha ebushelelezi. Izakhiwo zayo ze-antihypertensive, ezihambisana nemiphumela ye-cardioprotective, ziyenza ibe umuthi obalulekile wokulawula umfutho wegazi ophakeme kanye ne-angina pectoris ezinzile. Ezimweni ezithile ezifana ne-angina engazinzile nezinye izimo ezihlobene, i-eledoisin ingase futhi ibambe iqhaza ekuthuthukiseni impilo yenhliziyo nezimpawu zenhliziyo. Ngezindlela zayo ezinezici eziningi namandla okwelapha, i-eledoisin Acetate inesithembiso njengendlela yokwelapha yezimo ezihlukahlukene zenhliziyo.
