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Amathebulethi eLenopril Anika Amandla Ukulawula Umfutho Wegazi kanye Nempilo Yenhliziyo

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I-Flumazenil I-GABAA Receptor Antagonist ekhethiwe kanye nezicelo zayo zokwelapha

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I-Trametinib Kinase Inhibitor Targeting BRAF V600 Mutation-Positive Cancers

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I-Tirzepatide Dual GLP-1 kanye ne-GIP Receptor Agonist for Weight Management and Glycemic Control

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I-YK-11 I-SARM Enamandla Yokwakhiwa Kwemisipha, Ukuzuza Amandla, kanye Ne-Myostatin Inhibition

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I-Ostarine (MK-2866) I-SARM Eguquguqukayo Yokukhula Kwemisipha, Ukulahlekelwa Kwamafutha, Nokubuyiswa Komzimba

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I-Flumazenil I-GABAA Receptor Antagonist ekhethiwe kanye nezicelo zayo zokwelapha
I-Flumazenil I-GABAA Receptor Antagonist ekhethiwe kanye nezicelo zayo zokwelapha
I-Flumazenil I-GABAA Receptor Antagonist ekhethiwe kanye nezicelo zayo zokwelapha
I-Flumazenil I-GABAA Receptor Antagonist ekhethiwe kanye nezicelo zayo zokwelapha

I-Flumazenil I-GABAA Receptor Antagonist ekhethiwe kanye nezicelo zayo zokwelapha

Intengo Yereferensi:USD 1-2/g

  • Igama Lomkhiqizo I-Flumazenil
  • Inombolo ye-CAS. 78755-81-4
  • MF I-C15H14FN3O3
  • MW 303.288363
  • EINECS 616-650-9
  • Ukuminyana 1.39
  • Iphoyinti lokuncibilika 201-203 ℃
Xhumana nathi
imininingwane yomkhiqizo

Incazelo Eningiliziwe

I-Flumazenil, eyaziwa nangokuthi i-flumazepil noma igama lekhodi i-Ro 15-1788, iyimbangi ekhethiwe ye-GABAA receptor engalawulwa ngomjovo, ukufakwa kwe-otic, noma nge-intranasally. Isebenza njengokubili okuphikisayo kanye ne-antidote kuma-benzodiazepines, ikakhulukazi ezimeni zokudlula umthamo, ngokuvimbela ukuncintisana. Lesi sihloko sihlola izinzuzo zokwelapha, ukusetshenziswa njengekhambi, kanye nokusetshenziswa okungenzeka kwe-flumazenil kuzilungiselelo ezihlukahlukene zezokwelapha.

I. Indlela Yesenzo:
A. Umphikisi okhethiwe we-GABAA wamamukeli
B. Ukuvinjelwa kokuncintisana endaweni yokuqaphela i-benzodiazepine
C. Ukuguqulwa kwemiphumela ye-benzodiazepine

II. I-Antidote ye-Benzodiazepine Overdose:
A. Ukubaluleka kokuvinjelwa kokuncintisana ezimweni ze-overdose
B. Izinzuzo ze-flumazenil ekubuyiseleni ukudambisa ngokweqile
C. Izinkinga nezingozi ezihlobene nokusetshenziswa kokunakekelwa okubucayi
D. Ukucatshangelwa kwemithamo eminingi kanye nokuqapha ngokucophelela

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III. Isicelo sangemuva kokuhlinzwa:

A. Ukuguqulwa kwemithelela yokulalisa ye-benzodiazepines ngemva kokuhlinzwa

B. Ukufana nokusetshenziswa kwe-naloxone ekuguquleni i-opioid

C. Ukuqapha kukadokotela obulala izinzwa kanye nokucatshangelwa kwangemva kokuhlinzwa


IV. Ukwelashwa kwe-non-Benzodiazepine Hypnotic Overdoses:

A. Ukusebenza kwe-flumazenil ekwelapheni i-zolpidem, i-zaleplon, ne-zopiclone overdose


V. Izinhlelo zokusebenza ezingaba khona ku-Hypersomnia kanye Nemiphumela Emibi Yesisu:

A. Ukwehliswa kokulala okwedlulele kwasemini ku-hypersomnias eyinhloko

B. Ukuncishiswa kwemiphumela emibi emathunjini ebangelwa ukwelashwa komdlavuza

C. Ukuvikelwa kwama-stem cells ngesikhathi se-chemotherapy kanye nokwelashwa ngemisebe


VI. Ukubaluleka Kokulinganisa I-GABAA Receptor Inhibition:

A. Ukuvikela ama-stem cells emonakalweni we-DNA phakathi ne-radiotherapy

B. Ukuqinisekisa ukubulawa kwamangqamuzana omdlavuza akuphazamiseki



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I-Flumazenil, i-GABAA receptor antagonist ekhethiwe, isebenza njenge-antidote ebalulekile ezimweni ze-benzodiazepine overdose, enikeza ukuvinjelwa kokuncintisana nokuguqulwa kwemiphumela yokudambisa. Izicelo zayo zidlulela ekusetshenzisweni kwangemva kokuhlinzwa, ukwelashwa kwe-non-benzodiazepine hypnotic overdose, kanye nezinzuzo ezingaba khona ku-hypersomnia kanye nemiphumela emibi yesisu. Ukuqapha ngokucophelela nokucatshangelwa kwezingozi kubalulekile lapho unikeza i-flumazenil, ikakhulukazi ezindaweni zokunakekelwa okubuhlungu kanye nezilungiselelo zangemuva kokuhlinzwa. Ucwaningo olwengeziwe luyadingeka ukuhlola amandla alo aphelele ekuvikeleni ama-stem cells ngesikhathi sokwelashwa komdlavuza kuyilapho kugcinwa ukusebenza kahle kokubulawa kwamangqamuzana omdlavuza.

Ukucaciswa

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