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Amathebulethi eLenopril Anika Amandla Ukulawula Umfutho Wegazi kanye Nempilo Yenhliziyo

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I-Flumazenil I-GABAA Receptor Antagonist ekhethiwe kanye nezicelo zayo zokwelapha

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I-Trametinib Kinase Inhibitor Targeting BRAF V600 Mutation-Positive Cancers

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I-Tirzepatide Dual GLP-1 kanye ne-GIP Receptor Agonist for Weight Management and Glycemic Control

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I-Cisapride Gastric Stimulant for Indigestion and Digestive Disorders

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I-YK-11 I-SARM Enamandla Yokwakhiwa Kwemisipha, Ukuzuza Amandla, kanye Ne-Myostatin Inhibition

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I-Leuprorelin Hormone Therapy ye-Prostate kanye Nomdlavuza Webele
I-Leuprorelin Hormone Therapy ye-Prostate kanye Nomdlavuza Webele
I-Leuprorelin Hormone Therapy ye-Prostate kanye Nomdlavuza Webele

I-Leuprorelin Hormone Therapy ye-Prostate kanye Nomdlavuza Webele

Intengo yesithenjwa: USD 30-100

  • Igama lomkhiqizo I-Leuprorelin
  • Inombolo ye-CAS. 53714-56-0
  • Ukuminyana 1.44
  • Iphoyinti lokuncibilika 150-155°C
  • Iphuzu elibilayo 1720.5°C ku-760 mmHg
  • MF I-C59H84N16O12
  • MW 1269.473
  • Inkomba ye-refractive 1.681
  • Iphoyinti le-Flash 994.3°C
Xhumana nathi
imininingwane yomkhiqizo

Incazelo Eningiliziwe

I-Leuprorelin, eyaziwa nangokuthi i-Lupron noma i-Prostap, i-hormone therapy esetshenziselwa ukwelapha i-prostate kanye nomdlavuza webele. Kungokwesigaba semithi ebizwa ngokuthi i-gonadotropin-releasing hormone (GnRH) agonists. Kule ndatshana, sizogxila ekusetshenzisweni kwayo ekwelashweni komdlavuza wendlala yesinye kanye nomdlavuza webele.

Ukwelashwa Kwe-Prostate Cancer:
I-Leuprorelin ivame ukusetshenziselwa ukwelapha umdlavuza wendlala yesinye. Isebenza ngokwehlisa izinga le-testosterone elikhiqizwa amasende. Amaseli omdlavuza wendlala yesinye ancike ku-testosterone ukuze akhule, ngakho ukwehlisa amazinga awo kunganciphisa umdlavuza noma kubambezele ukukhula kwawo. Ukuphathwa kwe-leuprorelin kusiza ukulawula izimpawu ezihlobene nomdlavuza wendlala yesinye osethuthukile futhi kuthuthukisa izinga lempilo yesiguli.

Ukwelapha Umdlavuza Webele:
I-Leuprorelin iphinde isetshenziswe ekwelapheni izinhlobo ezithile zomdlavuza webele. Isetshenziswa ngokukhethekile ezimeni lapho amangqamuzana omdlavuza ane-estrogen receptors (ER positive) futhi isiguli singazange sidlule ekunqamukeni kokuya esikhathini. I-Leuprorelin yehlisa izinga le-estrogen emzimbeni ngokucindezela ukukhiqizwa kwayo kuma-ovari. Lokhu kubalulekile ngoba amazinga aphezulu e-estrogen angakhuthaza ukukhula kwamangqamuzana omdlavuza webele. I-Leuprorelin ingase inikezwe yodwa noma ihlanganiswe nezinye izindlela zokwelapha ze-hormone ukuze ulawule ngempumelelo umdlavuza webele.


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I-Central Precocious Puberty:

Umjovo we-Leuprorelin, owaziwa nge-Lupron Depot-PED, usetshenziswa ezinganeni ezineminyaka engu-2 nangaphezulu ukwelapha i-central precocious puberty (CPP). I-CPP yisimo lapho amantombazane (ngokuvamile angaphansi kweminyaka engu-8 ubudala) kanye nabafana (imvamisa abancane kuneminyaka engu-9 ubudala) bangena esikhathini sokuthomba ngaphambi kwesikhathi. I-Leuprorelin isiza ukulawula isikhathi sokuthomba ngokunciphisa ukukhula kwamathambo okusheshayo nokuthuthukiswa kwezici zocansi ezihlobene ne-CPP.


Okunye Ukusetshenziswa Komtholampilo:

Umjovo we-Leuprorelin, owaziwa nangokuthi i-Lupron Depot, usetshenziswa ekwelapheni i-endometriosis kanye ne-anemia ebangelwa yi-uterine fibroids. Isebenza ngokunciphisa amazinga amahomoni athile emzimbeni, inikeze ukukhululeka ezimpawini ezinjengobuhlungu, ukuya esikhathini esindayo noma okungajwayelekile, kanye ne-anemia. Ukwengeza, i-leuprorelin ingasetshenziswa njengokwelashwa kwangaphambili kwezokwelapha ngaphambi kokukhishwa kwe-endometrial, njengoba yenza i-endometrium ibe mncane, inciphisa i-edema, futhi yenza kube lula inqubo yokuhlinzwa.


I-Pharmacokinetics:
I-Leuprorelin acetate ayisebenzi uma ithathwa ngomlomo futhi esikhundleni salokho ilawulwa ngomjovo ongaphansi kwesikhumba noma we-intramuscular. Ukulandela umjovo owodwa we-subcutaneous we-3.75 mg, ukuhlushwa okuphezulu kwe-plasma kufinyelelwa phakathi kwezinsuku ezi-1 kuya kwezi-2, namazinga we-1 kuya ku-2 ng/ml. Ekwelashweni komdlavuza wendlala yesinye, umjovo ongaphansi kwesikhumba we-3.75 mg unikezwa njalo emavikini ama-4 ngesamba semijovo emi-3 ukuze kuzuzwe ukugxiliswa kwe-plasma okuzinzile kwe-0.1 kuya ku-1 ng/ml. I-Leuprorelin igaywa ibe yimikhiqizo emine ewohlokayo emzimbeni futhi ikhishwe ikakhulukazi ngezinso.

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Isiphetho:
I-Leuprorelin, i-agonist ye-GnRH, iwukwelapha okubalulekile kwe-hormone esetshenziswa ekwelapheni i-prostate kanye nomdlavuza webele, kanye nokuthomba okuphakathi ngaphambi kwesikhathi, i-endometriosis, kanye ne-anemia ebangelwa ama-uterine fibroids. Ngokunciphisa amazinga e-testosterone noma e-estrogen, i-leuprorelin isiza ukulawula ukukhula nezimpawu ezihlobene nalezi zimo. Ukuphathwa kwe-leuprorelin kudinga ukuqondiswa kwezokwelapha kanye nokuqapha njalo ukuze kuqinisekiswe ukusebenza kwayo nokulawula noma yimiphi imiphumela emibi engase ibe khona.

Khumbula ukuxhumana nathi ukuze uthole imininingwane yamafomu okupakisha nawokuthumela, sizohlinzeka ngezinsizakalo zokwenza ngokwezifiso ze-OEM/ODM.

Ukucaciswa

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