0102030405
I-Memantine HCl 99%I-Purity yelapha isifo se-Alzheimer's Factory Supply
Incazelo Eningiliziwe
I-Memantine hydrochloride, eyakhiwa uMerz eJalimane, iyisidakamizwa esinoveli ekuqaleni esasihloselwe ukwelapha ukuwohloka komqondo. Isebenza njenge-N-methyl-D-aspartate (NMDA) receptor antagonist engeyona yokuncintisana, ivimbe ama-NMDA receptors futhi yehlise i-hyperexcitability eyenziwe yi-glutamate. Lo mshini uhlose ukuthuthukisa ukusebenza kwengqondo, ukuvimbela i-apoptosis, nokuthuthukisa inkumbulo. I-Pethidine hydrochloride yagunyazwa yiKomidi LaseYurophu Lemikhiqizo Yemithi Enelungelo Lobunikazi (CPMP) ukuze kwelashwe isifo se-Alzheimer's esimaphakathi kuya kwesinzima ngo-2002. Ucwaningo olwengeziwe luphinde lwabonisa ukusebenza kahle kwayo ezigulini ezinesifo i-Alzheimer's emaphakathi kuya komaphakathi.
I-Memantine hydrochloride, isithako esisebenzayo ku-pethidine hydrochloride, iwukuhlangana okumaphakathi, okungeyona incintisana ye-NMDA receptor antagonist. Nakuba ukusetshenziswa kwayo okuyinhloko kuwukwelashwa kwesifo i-Alzheimer's, kuye kwacwaningwa kabanzi futhi kusetshenziselwe ezinye izinkinga zesimiso sezinzwa esimaphakathi njengesithuthwane, imigraines, nezimo zengqondo ezihlanganisa i-bipolar disorder kanye ne-schizophrenia. Ukuwohloka komqondo kuseyiyona nto okugxilwe kuyo kakhulu ekusetshenzisweni kwe-memantine, futhi ibonise amazinga ahlukahlukene ezinzuzo ku-Alzheimer's, ukuwohloka komqondo kwemithambo, nokuwohloka komqondo ngemizimba ka-Lewy. Ayithuthukisi nje kuphela ukusebenza kwengqondo kodwa futhi ibhekana nezimpawu zokuziphatha nezingokwengqondo zokuwohloka komqondo (BPSD), njengokubona izinto ezingekho, ukukhohlisa, ukuyaluza, ulaka, nokucasuka.
Ngaphezu komthelela wayo ekuwohlokeni komqondo, i-memantine iye yaphenywa ngemiphumela yayo kwezinye izifo zemizwa. Iziguli ezinesifo sokuwa zivame ukuba nokushoda kwengqondo, futhi i-memantine ibonise amandla ekwehliseni lokhu kusilela. Ngaphezu kwalokho, isifo i-Alzheimer's ngokwaso siyingozi yokuquleka, futhi abantu abanalesi sifo basengozini enkulu yokuba nesifo sokuwa uma beqhathaniswa nalabo abangenaso i-Alzheimer's. Ngokuvimbela i-neuroexcitotoxicity ehambisana ne-NMDA receptor hyperactivation, i-memantine ingase ibe nemiphumela ye-antiepileptic.
Ngaphezu kwalokho, i-memantine iye yacutshungulwa kumongo wokwelashwa ngemisebe yobuchopho obuphelele (WBRT), ukulimala kobuchopho okubuhlungu (TBI), kanye nokushaywa unhlangothi. I-WBRT ingaholela ekulimaleni kwengqondo, futhi i-memantine iye yaboniswa ibambezela ukuqala kwayo futhi ithuthukise ukusebenza kwengqondo. Izakhiwo eziyingqayizivele ze-pharmacological ze-memantine ziye zaholela ekuhloleni kwayo ezinhlobonhlobo zezinkinga ze-neurological.
Ucwaningo lwakamuva luye lwaphakamisa ngisho nokusetshenziswa okungenzeka kwe-memantine ekudambiseni imiphumela ye-neurotoxic ye-COVID-19 futhi kuvinjwe ukuphindaphindeka kwegciwane, okubonisa ukwanda kwayo komtholampilo.
I-Memantine hydrochloride, ikakhulukazi isithako sayo esisebenzayo i-memantine hydrochloride, ibonise ukusebenza ngempumelelo ekwelapheni ukuwohloka komqondo, ikakhulukazi isifo i-Alzheimer's. Indlela yayo eyingqayizivele njengomphikisi we-NMDA receptor ivumela ukuthuthukiswa komsebenzi wokuqonda kanye nokuphathwa kwezimpawu zokuziphatha nezingokwengqondo ezihambisana nokuwohloka komqondo. Ngaphezu kwalokho, i-memantine ibonisa isithembiso kwezinye izifo zemizwa ezifana nesifo sokuwa, i-migraines, nokukhubazeka kokuqonda kwangemuva kokukhipha imisebe. Ucwaningo oluqhubekayo luyaqhubeka nokuhlola inani lomtholampilo elingase libe khona le-memantine ezimweni ezihlukahlukene zezinzwa.
Khumbula ukuxhumana nathi ukuze uthole umhlahlandlela onempilo.
Khumbula ukuxhumana nathi ukuze uthole umhlahlandlela onempilo.
Ukucaciswa
