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Amathebulethi eLenopril Anika Amandla Ukulawula Umfutho Wegazi kanye Nempilo Yenhliziyo

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I-Flumazenil I-GABAA Receptor Antagonist ekhethiwe kanye nezicelo zayo zokwelapha

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I-rosuvastatin antilipemic ejenti I-Rosuvastatin yelapha i-dyslipidemia
I-rosuvastatin antilipemic ejenti I-Rosuvastatin yelapha i-dyslipidemia
I-rosuvastatin antilipemic ejenti I-Rosuvastatin yelapha i-dyslipidemia
I-rosuvastatin antilipemic ejenti I-Rosuvastatin yelapha i-dyslipidemia

I-rosuvastatin antilipemic ejenti I-Rosuvastatin yelapha i-dyslipidemia

Intengo yesithenjwa: USD 5-10/g

  • Igama Lomkhiqizo I-Rosuvastatin
  • Inombolo ye-CAS. 287714-41-4
  • MF I-C22H28FN3O6S
  • MW 481.54
  • EINECS 689-191-5
  • Ukuminyana 1.368±0.06 g/cm3(Kubikezelwe)
  • Iphoyinti lokuncibilika 161.9 °C
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Incazelo Eningiliziwe

I-Rosuvastatin isidakamizwa esinqunyelwe ukwelapha i-hypercholesterolemia nezinye izimo ezihlobene nayo. Lesi sidakamizwa, esaziwa ngokuthi ama-statins, sisetshenziswa ngokuhambisana nokuzivocavoca, ukulawula ukudla, nokuncipha kwesisindo sokuthuthukisa amazinga e-cholesterol nokuvikela isifo senhliziyo. Le ndatshana izohlola izindlela zokwenza kanye nokusetshenziswa komtholampilo kwe-rosuvastatin, kanye nemiphumela yayo kokungajwayelekile kwe-lipid kanye nempilo yonke yenhliziyo nemithambo yegazi.

I-Rosuvastatin, ehlukaniswa njenge-ejenti ye-antilipemic kanye nelungu lesigaba semithi ye-statin, isetshenziselwa ngokuyinhloko ukwelapha i-dyslipidemia, kuhlanganise ne-cholesterol ephezulu. Isebenza ngokuvimbela i-enzyme ebandakanyeka ekukhiqizweni kwe-cholesterol emzimbeni, okuholela ekwehleni kwamazinga e-cholesterol ephelele kanye ne-triglycerides, kuyilapho ngasikhathi sinye inyusa amazinga e-high-density lipoprotein (HDL) cholesterol, evame ukubizwa ngokuthi i-cholesterol "enhle". I-rosuvastatin iphumelela kakhulu uma ihlanganiswa nokudla okunempilo kanye nohlelo lokuzivocavoca. Ukwengeza, isetshenziselwa ukwelapha abantu abanezinkinga ezithile ezizuzwe njengefa le-cholesterol. Ukusetshenziswa komtholampilo kwe-rosuvastatin kufaka phakathi ukwelashwa kwe-hypercholesterolemia eyinhloko, i-hypercholesterolemia yomndeni, kanye nokuphazamiseka kwe-lipid okubangelwa ezinye izici.


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I-rosuvastatin ivimbela i-enzyme i-hydroxymethylglutaryl-CoA reductase esibindini, enciphisa ukwakheka kwe-cholesterol futhi yehlise i-serum cholesterol kanye namazinga e-triglyceride. Ngaphezu kwalokho, i-rosuvastatin inyusa ukumukeka kwesibindi nokuwohloka kwe-low-density lipoprotein cholesterol (LDL-C), kuyilapho inyusa amazinga e-high-density lipoprotein cholesterol (HDL-C). Ngokungeziwe emiphumeleni yayo yokwehlisa i-lipid, i-rosuvastatin iboniswe ukuthi ine-anti-atherosclerotic, anti-inflammatory, antioxidant, plaque stabilizing, kanye nezakhiwo ezithuthukisiwe ze-endothelial.

I-Rosuvastatin ikhiqizwa ngokuvutshelwa kwe-Aspergillus terreus noma ngokuhlanganiswa kwamakhemikhali. Uma isingenisiwe, igaywa kakhulu esibindini bese iguqulwa ibe ama-metabolites ahlukahlukene, okuhlanganisa nama-metabolites asebenzayo avimbela i-HMG-CoA reductase. Umuthi kanye nama-metabolites awo akhishwa ngokuyinhloko endle, ngenani elincane elikhishwa emchameni.


Ngokuncintisana ngokuvimbela i-HMG-CoA reductase, i-enzyme enciphisa izinga ku-cholesterol synthesis, i-lovastatin yehlisa ukukhiqizwa kwe-cholesterol endo native futhi ikhuphule ukubonakaliswa kwama-LDL receptors kumaseli esibindi. Lokhu kubangela ukwanda kwezinga lokucaciswa kwe-cholesterol ye-LDL. I-Lovastatin isiza futhi ukwehlisa amazinga e-serum triglyceride futhi ikhulise amazinga e-HDL cholesterol, okunomthelela ekuvimbeleni nasekwelapheni i-atherosclerosis nesifo senhliziyo.

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I-Rosuvastatin imithi ebalulekile yokwelapha i-hypercholesterolemia kanye nezimo ezihlobene nayo. I-Rosuvastatin isebenza ngokuyinhloko ngokuvimbela ukukhiqizwa kwe-cholesterol nokuthuthukisa amazinga e-cholesterol ngokuhlanganiswa nokuguqulwa kwendlela yokuphila. Ngakolunye uhlangothi, ivimbela ukwakheka kwe-cholesterol futhi ikhuphule ukumukeka kwesibindi nokuwohloka kwe-cholesterol ye-LDL, okuholela ekwehleni kwe-cholesterol namazinga e-triglyceride. Ibonise ukusebenza kahle ekuthuthukiseni ukungahambi kahle kwe-lipid kanye nempilo yonke yenhliziyo nemithambo yegazi. Kubalulekile ukuthintana nathi ukuze uthole inkomba yochwepheshe bezokunakekelwa kwempilo ukuze sinqume ukusetshenziswa okufanele kanye nomthamo wale mithi ngokusekelwe ezidingweni zomuntu ngamunye kanye nomlando wezokwelapha.

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