I-Triptorelin, i-decapeptide yokwenziwa kanye ne-analog ye-gonadotropin-releasing hormone (GnRH) yemvelo, ithole ukuqashelwa okubalulekile emkhakheni wezokwelapha. Isetshenziselwa izinkomba ezihlukahlukene, okuhlanganisa ukwelashwa kwe-endometriosis, i-fibroids, umdlavuza we-prostate, ukuthomba ngaphambi kwesikhathi, kanye nokungazali. I-Triptorelin isebenza ngokuqala ikhuthaze ukukhiqizwa kwe-gonadotropins futhi kamuva yehlise i-gonadotropin-ekhulula ama-hormone receptors, okuholela ekuncipheni kwesikhathi eside kokukhululwa kwe-gonadotropin.
I-Triptorelin ikhombisa uhla olubanzi lwemiphumela yokwelapha. Kwabesifazane, isetshenziselwa ukuphatha i-endometriosis, i-uterine fibroids, nokungazali. Ukuphatha okuqhubekayo kwe-Triptorelin kuvimbela ngempumelelo ukukhiqizwa kwe-estradiol, okuholela ekucindezelweni kwezicubu ze-ectopic endometrial ku-endometriosis. Ukwengeza, ucwaningo lubonise ukwehla okukhulu kobukhulu be-uterine fibroids, neziguli eziningi ezithola i-amenorrhea ngemva kwenyanga yokuqala yokwelashwa. Ngokungazali, i-tritorelin ivimbela ukukhishwa kwe-gonadotropin, ithuthukisa ikhwalithi yokukhiqizwa kwe-follicle futhi ikhulise inani lama-follicles, ngaleyo ndlela ikhulise amathuba okusizwa ngempumelelo amasu okuzala njengokuvundiswa kwe-in vitro.
Kwabesilisa, i-tritorelin ijwayele ukusetshenziselwa ukuphatha umdlavuza wendlala yesinye. Isebenza ngokukhuphula ekuqaleni i-blood luteinizing hormone (LH) kanye namazinga e-follicle-stimulating hormone (FSH), okulandelwa ukwehla kwala mahomoni kanye nokwehla kwamazinga e-testosterone egazini. Lokhu kuncipha kwamazinga e-testosterone kusiza ekwelapheni umdlavuza wendlala yesinye kanye nezimpawu ezihambisana nawo. Imijovo ye-Triptorelin nayo isebenze kahle ekwelapheni ukuthomba ngaphambi kwesikhathi, ivimbela i-pituitary hypersecretion ye-gonadotropin kanye namazinga e-hormone ajwayelekile.
Izindlela zokwenza ze-triptorelin zibandakanya kokubili ukucindezelwa kwemfihlo ye-gonadotropin kanye nokuvimbela okuqondile kwe-gonadotropic ngokuqeda uzwela kuma-peripheral GnRH receptors. Ucwaningo lwezilwane nelomuntu lubonise imiphumela evimbelayo yokusetshenziswa okungapheli kwe-triptorelin ekukhiqizweni kwe-gonadotropin, okuholela ekucindezelweni kokusebenza kwe-testicular kanye ne-ovarian. Ukusebenza kwe-Triptorelin kufakazelwa futhi ukuthuthuka komtholampilo ezimpawu ezifana ne-dysmenorrhea, ubuhlungu be-pelvic obungapheli, nobuhlungu ngesikhathi sokuya ocansini.
Sikunikeza izixazululo ezahlukahlukene ezenziwe ngokwezifiso ongakhetha kuzo
Umjovo we-Triptorelin: 0.1 mg/1 ml.
I-Triptorelin umjovo wokukhululwa okunwetshiwe: 3.75 mg; 11.25 mg; 22.5 mg.
I-Triptorelin pamoate yokujova: 15 mg ibhodlela ngalinye (eliqukethe ibhodlela eli-1 le-solvent engu-2 ml). Uma unezinye izidingo, ungaphinda usithinte futhi sizokunikeza ngezinsizakalo zokwenza ngokwezifiso ezisheshayo nezinembayo.
Njenge-analog ye-gonadotropin enamandla, i-Triptorelin inikeza uhla lwezicelo zokwelapha zabesilisa nabesifazane. Amandla ayo okulawula amazinga e-hormone kanye nokuvimbela ukukhishwa kwe-gonadotropin afakazele ukuthi asebenza kahle ekulawuleni izimo ezifana ne-endometriosis, i-uterine fibroids, umdlavuza wendlala yesinye, ukuthomba ngaphambi kwesikhathi, kanye nokungazali. Ngokusebenza kahle komtholampilo kanye nokuguquguquka, i-tritorelin iyaqhubeka nokufaka isandla kakhulu emkhakheni wezokwelapha zokuzala kanye ne-oncology.Ukuqonda izindlela zokwenza kanye namalungiselelo atholakalayo e-triporelin kuvumela ochwepheshe bezempilo ukuthi bahlele izinhlelo zokwelashwa ezidingweni zesiguli ngasinye.
