0102030405
I-Vincristine Sulfate Powder I-Vincristine Purity Vincristine CAS 57-22-7
Incazelo Eningiliziwe
I-Vincristine iyi-crystalline powder emhlophe kuya kokumhlophe. Ayincibiliki emanzini, kodwa incibilika kwezinye izinyibilikisi eziphilayo.Inhlanganisela emsulwa ayinaphunga futhi ivamise ukugcinwa endaweni eyomile, emnyama ngaphansi kwezimo zokushisa ezilawulwayo ukuze kugcinwe ukuzinza. I-alkaloid eyenzeka ngokwemvelo etholakala esitshalweni saseMadagascar i-periwinkle(Catharanthus roseus).Isakhiwo sayo samakhemikhali sifana ne-vinblastine,enye i-vinca alkaloid. .
I-Vincristine iyi-microtubule inhibitor ephazamisa ukwakheka kwama-microtubules, okuyizingxenye ezibalulekile ze-cytoskeleton yeseli. I-vincristine isebenza ngokukhethekile ngokumelene namangqamuzana omdlavuza ahlukana ngokushesha.Izicelo zomtholampilo ze-vincristine zihlanganisa ukwelashwa kwezifo ezihlukahlukene ezifana ne-acute lymphoblastic leukemia(ALL),Hodgkin's kanye ne-non-Hodgkin's lymphomas,izicubu zezingane kanye neziqinile zabantu abadala,i-neuroblastoma, kanye ne-rhabdomyosarcoma.I-Vincristine ivame ukusetshenziswa. ngokuhlanganiswa namanye ama-chemotherapeutic agents njengengxenye yemithi yokwelashwa kwezidakamizwa eziningi, eyaziwa ngokuthi yinhlanganisela ye-chemotherapy.
Ngaphezu kokusetshenziswa kwayo okuyinhloko ekwelapheni umdlavuza, i-vincristine iphinde yabonisa ukusebenza kahle ekulawuleni izimo ezithile ezingezona eze-oncological. ,i-vincristine ibonise amandla ekulawuleni izimo ezihlukahlukene zemizwa, okuhlanganisa ukuvuvukala okungapheli kwe-polyneuropathy(CIDP) kanye nezifo ze-autoimmune neuropsychiatric zezingane ezihambisana nezifo ze-streptococcal(PANDAS).
Ngaphezu kwalokho, izakhiwo ze-vincristine zokulwa ne-angiogenic ziholele ekuhloleni ukusetshenziswa kwayo okungaba khona ekwelapheni izifo ezihlukahlukene ezikhulayo, okuhlanganisa i-retinopathy yesifo sikashukela kanye nokuwohloka kwe-macular okuhlobene nobudala. ezinye izimo zezokwelapha zibhekwa njengezingekho kulebula futhi zidinga ukuhlolwa ngokucophelela kwezingozi ezingase zibe khona kanye nezinzuzo.Kafushane, i-vincristine, etholakala esitshalweni saseMadagascar i-periwinkle, iyi-ejenti ebalulekile yokulwa nomdlavuza ephazamisa ukwakheka kwe-microtubule futhi ibangele ukufa kwamangqamuzana ahlukanisa amaseli. Izicelo zomtholampilo ezibanzi zihlanganisa ukwelashwa kwe-leukemia, i-lymphoma, izimila eziqinile, nezimo ezithile ezingezona ze-oncological. Nakuba ukusetshenziswa kwayo okuyinhloko kusekwelapheni umdlavuza, ucwaningo oluqhubekayo luyaqhubeka nokuhlola amandla ayo ezimeni ezihlukahlukene zezokwelapha.
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