Arecoline hydrobromide Therapeutic Potential in Central nervous system

Reference Price: USD15-20/g

Product Name Arecoline
CAS No. 300-08-3
MF C8H14BrNO2
MW 236.109
EINECS 206-087-3
Acidity coefficient (pka) 6.84(at 25℃)
Melting point 171-175°C

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Detailed Description

Arecoline, the principal active alkaloid found in the areca nut, has gained attention for its therapeutic potential in addressing psychiatric disorders and alleviating gastrointestinal ailments. This article aims to provide a systematic summary of the mechanism of action of arecoline in various bodily systems, including the oral cavity, central nervous system, cardiovascular system, and digestive system. Additionally, the health functions and potential toxic effects of arecoline will be explored. Finally, the applications of arecoline in health food supplements, pharmaceuticals, and cosmetic preparations will be discussed.

Arecoline, a nicotinic acid-based mild parasympathomimetic stimulant alkaloid, primarily acts as a partial agonist of muscarinic acetylcholine receptors. It exhibits parasympathetic effects instead of agonizing nicotinic acetylcholine receptors like nicotine. Arecoline also inhibits AMPK (adenosine monophosphate-activated protein kinase) through the generation of reactive oxygen species (ROS) in various cell types.

Effects on Different Body Systems:

Nervous System: Arecoline promotes excitation, enhances learning and memory, and decreases symptoms of depression and schizophrenia. It can also reverse memory loss induced by scopolamine.

Cardiovascular System: Arecoline acts as a vasodilator, increases plasma nitric oxide, eNos, and mRNA expression, and exhibits anti-thrombosis and anti-atherogenic effects. It also downregulates IL-8 and other factors.

Endocrine System: Arecoline stimulates Leydig's cells, leading to increased testosterone levels. It activates the hypothalamic-pituitary-adrenal (HPA) axis, stimulating corticotropin-releasing hormone (CRH) release. Additionally, it helps prevent dysfunction of pancreatic beta cells caused by high fructose intake.

Digestive System: Arecoline stimulates the digestive system through the activation of muscarinic receptors. It increases contractions of gastric smooth muscle and muscle strips of the duodenum, ileum, and colon.

Health Functions and Applications:

Analgesia and Central Nervous System Effects: Arecoline hydrobromide exhibits analgesic properties and has a stabilizing effect on the central nervous system.

Skin Health: Arecoline hydrobromide promotes skin metabolism and shows potential for treating skin ulcers and other skin diseases.

Detoxification and Diuretic Effects: Arecoline hydrobromide clears heat, detoxifies, eliminates dampnessand swelling, and has diuretic properties.

Antibacterial and Dissolving Stones: Arecoline hydrobromide demonstrates antibacterial properties and the ability to dissolve stones.

Blood Vessel Strengthening and Blood Circulation: Arecoline hydrobromide helps strengthen blood vessels and promote blood circulation.

Applications:

Health Food Supplements: Arecoline can be used as an ingredient in health food supplements targeting specific health functions, such as cognitive enhancement or skin health.

Pharmaceuticals: Arecoline may have potential applications in pharmaceuticals, particularly in the treatment of psychiatric disorders or as an antihelmintic drug.

Cosmetic Preparation: Arecoline's skin metabolism promotion and potential wound healing properties make it a candidate for cosmetic preparations, particularly those targeting skin ulcers or other skin-related ailments.

Arecoline, the active alkaloid found in the areca nut, exhibits various therapeutic effects and has applications in different body systems. Its mechanisms of action are primarily mediated through muscarinic receptors and exhibit parasympathetic effects. While arecoline shows promise in addressing certain health conditions, it is important to consider the potential toxic effects and carcinogenic properties associated with its use.Contact with us if in need.

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