Cisplatin Powder Cisplatin Purity 99% Cisplatin Pharmaceutical

Product Name Cisplatin
Appearance Orange-yellow to dark yellow crystalline powder
CAS No. 15663-27-1
Chemical Formula Cl2H6N2Pt
Molecular weight 300.05
Melting point 270℃
Density 3.7

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Detailed Description

Cisplatin,also known by its trade name Platinol,is a chemotherapy medication used to treat various types of cancer.

Appearance:Cisplatin is a white to off-white crystalline powder with a faint characteristic odor.It is sparingly soluble in water but dissolves in chloride-containing solutions and some organic solvents.The pure compound is generally stored in a dry,dark place under controlled temperature conditions to maintain its stability.When properly stored,cisplatin maintains its chemical integrity and potency.It was first synthesized in 1844 by Alfred Werner,a Swiss chemist who received the Nobel Prize in Chemistry in 1913 for his work on coordination compounds.Cisplatin was later investigated for its potential anticancer properties and was found to be effective in the treatment of various malignancies.

Function and Applications:Cisplatin is classified as a platinum-based chemotherapy drug and is part of the family of alkylating agents.It exerts its anticancer effects by forming covalent bonds with DNA,leading to the disruption of cellular functions and ultimately causing cell death.Specifically,cisplatin binds to the purine bases in DNA,forming intrastrand and interstrand crosslinks.These crosslinks interfere with DNA replication and transcription,leading to the inhibition of cell proliferation and the induction of apoptosis in cancer cells.Cisplatin is widely used in the treatment of various types of cancer,including testicular,ovarian,bladder,head and neck,lung,and cervical cancers.

It is often part of combination chemotherapy regimens and is administered intravenously in a clinical setting under the supervision of healthcare professionals.The combination of cisplatin with other chemotherapeutic agents,such as etoposide,bleomycin,and fluorouracil,has demonstrated synergistic effects in the treatment of certain malignancies.In addition to its primary role in solid tumor malignancies,cisplatin is also used in the treatment of germ cell tumors,both as a single agent and in combination with other chemotherapy drugs.It has demonstrated effectiveness in the management of metastatic testicular cancer,particularly when used in combination with other platinum-based agents such as etoposide and bleomycin.Furthermore,cisplatin has been studied for its potential application in other cancer types,including esophageal,gastric,and pancreatic cancers.

Research continues to explore its efficacy in combination with novel targeted therapies and immunotherapies to enhance treatment outcomes and reduce the development of resistance.Aside from cancer treatment,cisplatin has also been investigated for its potential use in localized hyperthermia therapy,which involves heating specific areas of the body to kill cancer cells or make them more sensitive to other treatments.In this context,cisplatin is used in combination with heat to enhance its cytotoxic effects within the tumor microenvironment.

In summary,cisplatin is a synthetic platinum-based chemotherapy drug that exerts its anticancer effects by forming DNA crosslinks and inducing cell death in cancer cells.Its widespread clinical applications include the treatment of testicular,ovarian,bladder,head and neck,lung,and cervical cancers,with ongoing research exploring its potential in other malignancies.Additionally,cisplatin has potential applications in hyperthermia therapy and continues to be an essential component of combination chemotherapy regimens.