Eledoisin Acetate, a member of the tachykinin family, is an active peptide with various physiological effects. It acts as a potent vasodilator and secretagogue, exerting its actions on smooth muscles. Eledoisin Acetate primarily exhibits strong angiotensin II vasoconstriction and increases blood pressure. Its mechanism involves arteriolar smooth muscle contraction, increased peripheral resistance, release of adrenal aldosterone leading to sodium retention and increased blood volume, direct contribution to renal tubular sodium and water reabsorption, and stimulation of sympathetic vasoconstrictor activity in the brain, resulting in increased peripheral vascular resistance.
Eledoisin Acetate also possesses antihypertensive properties. It achieves this by blocking calcium channels, particularly the L-type calcium channels in coronary and peripheral vascular smooth muscle cells. By selectively inhibiting the entry of calcium ions into cells, eledoisin relaxes vascular smooth muscle cells, leading to peripheral blood vessel expansion, reduced peripheral resistance, and ultimately a lowering of blood pressure.
In addition to its antihypertensive effect, eledoisin offers cardioprotective benefits. By reducing the burden on the heart and decreasing cardiac oxygen consumption, it helps improve coronary blood flow, enhance myocardial oxygen supply, and alleviate symptoms of angina pectoris.Eledoisin is commonly used to treat primary or secondary hypertension. It can be used alone or in combination with other antihypertensive medications to effectively control blood pressure.Stable Angina Pectoris: Patients with stable angina pectoris caused by coronary heart disease can benefit from eledoisin treatment. It helps alleviate symptoms such as chest tightness and chest pain, providing relief and improving overall cardiovascular well-being.In cases of acute coronary syndrome, eledoisin may be considered to improve the patient's cardiovascular status, providing support and potentially reducing the risk of complications.
Eledoisin Acetate, a versatile peptide, demonstrates various physiological effects, including vasodilation, secretagogue activity, and modulation of smooth muscles. Its antihypertensive properties, coupled with cardioprotective effects, make it a valuable medication for managing hypertension and stable angina pectoris. In specific cases such as unstable angina and other related conditions, eledoisin may also play a role in improving cardiovascular health and symptoms. With its multifaceted mechanisms and therapeutic potential, eledoisin Acetate holds promise as a treatment option for various cardiovascular conditions.
