English
English French German Portuguese Spanish Russian Japanese Korean Arabic Irish Greek Turkish Italian Danish Romanian Indonesian Czech Afrikaans Swedish Polish Basque Catalan Esperanto Hindi Lao Albanian Amharic Armenian Azerbaijani Belarusian Bengali Bosnian Bulgarian Cebuano Chichewa Corsican Croatian Dutch Estonian Filipino Finnish Frisian Galician Georgian Gujarati Haitian Hausa Hawaiian Hebrew Hmong Hungarian Icelandic Igbo Javanese Kannada Kazakh Khmer Kurdish Kyrgyz Latin Latvian Lithuanian Luxembou.. Macedonian Malagasy Malay Malayalam Maltese Maori Marathi Mongolian Burmese Nepali Norwegian Pashto Persian Punjabi Serbian Sesotho Sinhala Slovak Slovenian Somali Samoan Scots Gaelic Shona Sindhi Sundanese Swahili Tajik Tamil Telugu Thai Ukrainian Urdu Uzbek Vietnamese Welsh Xhosa Yiddish Yoruba Zulu Kinyarwanda Tatar Oriya Turkmen Uyghur
Leave Your Message
Products Categories
Featured Products
Lenopril Tablets Empowering Blood Pressure Control and Cardiovascular Health

Lenopril Tablets Empowering Blood Pressure Control and Cardiovascular Health
Telmisartan Better antihypertensive Protecting renal

Telmisartan Better antihypertensive Protecting renal
Flumazenil A Selective GABAA Receptor Antagonist and its Therapeutic Applications

Flumazenil A Selective GABAA Receptor Antagonist and its Therapeutic Applications
Trametinib Kinase Inhibitor Targeting BRAF V600 Mutation-Positive Cancers

Trametinib Kinase Inhibitor Targeting BRAF V600 Mutation-Positive Cancers
Dabrafenib A Targeted Therapy for BRAF-Mutated Cancers

Dabrafenib A Targeted Therapy for BRAF-Mutated Cancers
Tirzepatide Dual GLP-1 and GIP Receptor Agonist for Weight Management and Glycemic Control

Tirzepatide Dual GLP-1 and GIP Receptor Agonist for Weight Management and Glycemic Control
Cisapride Gastric Stimulant for Indigestion and Digestive Disorders

Cisapride Gastric Stimulant for Indigestion and Digestive Disorders
YK-11 Potent SARM for Muscle Building, Strength Gains, and Myostatin Inhibition

YK-11 Potent SARM for Muscle Building, Strength Gains, and Myostatin Inhibition
Ostarine (MK-2866) Versatile SARM for Muscle Growth, Fat Loss, and Body Recomposition

Ostarine (MK-2866) Versatile SARM for Muscle Growth, Fat Loss, and Body Recomposition
MK-677 Unique Compound for Muscle Growth, Endurance, and Recovery

MK-677 Unique Compound for Muscle Growth, Endurance, and Recovery
0102030405
Flumazenil A Selective GABAA Receptor Antagonist and its Therapeutic Applications
Flumazenil A Selective GABAA Receptor Antagonist and its Therapeutic Applications
Flumazenil A Selective GABAA Receptor Antagonist and its Therapeutic Applications
Flumazenil A Selective GABAA Receptor Antagonist and its Therapeutic Applications

Flumazenil A Selective GABAA Receptor Antagonist and its Therapeutic Applications

Reference Price:USD 1-2/g

  • Product Name Flumazenil
  • CAS No. 78755-81-4
  • MF C15H14FN3O3
  • MW 303.288363
  • EINECS 616-650-9
  • Density 1.39
  • Melting point 201-203℃
Contact us
product details

Detailed Description

Flumazenil, also known as flumazepil or code name Ro 15-1788, is a selective GABAA receptor antagonist that can be administered via injection, otic insertion, or intranasally. It acts as both an antagonist and antidote to benzodiazepines, particularly in cases of overdose, through competitive inhibition. This article explores the therapeutic benefits, usage as an antidote, and potential applications of flumazenil in various medical settings.

I. Mechanism of Action:
A. Selective GABAA receptor antagonist
B. Competitive inhibition at the benzodiazepine recognition site
C. Reversal of benzodiazepine effects

II. Antidote for Benzodiazepine Overdose:
A. Importance of competitive inhibition in overdose cases
B. Benefits of flumazenil in reversing excessive sedation
C. Complications and risks associated with acute care use
D. Considerations for multiple dosing and careful monitoring

17163636651623zb

III. Post-Surgical Application:

A. Reversal of sedative effects of benzodiazepines after surgery

B. Similarities to naloxone's use in opioid reversal

C. Anesthesiologist monitoring and post-surgical considerations


IV. Treatment of Non-Benzodiazepine Hypnotic Overdoses:

A. Effectiveness of flumazenil in treating zolpidem, zaleplon, and zopiclone overdoses


V. Potential Applications in Hypersomnia and Gastrointestinal Side Effects:

A. Reduction of excessive daytime sleepiness in primary hypersomnias

B. Alleviation of gastrointestinal side effects caused by cancer treatments

C. Protection of intestinal stem cells during chemotherapy and radiation therapy


VI. Importance of Balancing GABAA Receptor Inhibition:

A. Protecting intestinal stem cells from DNA damage during radiotherapy

B. Ensuring cancer cell killing is not compromised



1716363224318wrf


Flumazenil, a selective GABAA receptor antagonist, serves as a valuable antidote in benzodiazepine overdose cases, offering competitive inhibition and reversal of sedative effects. Its applications extend to post-surgical use, treatment of non-benzodiazepine hypnotic overdoses, and potential benefits in hypersomnia and gastrointestinal side effects. Careful monitoring and consideration of risks are essential when administering flumazenil, particularly in acute care and post-surgical settings. Further research is needed to explore its full potential in protecting intestinal stem cells during cancer treatments while maintaining cancer cell-killing efficacy.

Specification

1716359370385iql