ʻO Dabrafenib He lāʻau lapaʻau i koho ʻia no nā maʻi maʻi maʻi BRAF-mutated
Ka wehewehe kikoʻī
II. Nā hōʻailona hōʻailona:
A. Monotherapy:
ʻO ka melanoma hiki ʻole ke wehe ʻia a i ʻole metastatic me ka hoʻololi ʻana o BRAF V600E
B. ʻO ka hui pū ʻana me ka trametinib:
BRAF V600E-maikaʻi hiki ʻole ke hoʻokaʻawale ʻia a i ʻole metastatic melanoma
Metastatic non-small cell lung cancer
Metastatic anaplastic thyroid cancer
ʻAʻole hiki ke hoʻokaʻawale ʻia a i ʻole ka metastatic solid tumors
III. Mechanism o ka hana:
A. Hoʻopaʻa koho a hoʻopaʻa i ka B-raf
B. Kāohi ʻana i ka hoʻonui ʻia ʻana o nā cell tumor me ka ʻano BRAF i hoʻololi ʻia
IV. Lapaʻau ʻana i ka maʻi maʻi thyroid:
A. ʻO kekahi ʻano o ka maʻi maʻi thyroid i laha i nā ʻiʻo kokoke a i ʻole nā wahi ʻē aʻe o ke kino
B. (mau) lapaʻau mua ʻana
Papa V. Kinase Inhibitor:
A. Dabrafenib ma ke ʻano he lālā o nā kinase inhibitors
B. Kāohi ʻana i ka hana protein ʻokoʻa no ka pale ʻana i ka hoʻonui ʻana o ka maʻi kanesa
Hōʻike
