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Linaclotide bụ Peptide dị iche iche maka ọrịa afọ na ahụike eriri afọ
Nkọwa zuru ezu
Linaclotide, peptide agonist nke guanylate cyclase 2C, apụtala dị ka nhọrọ ọgwụgwọ bara uru maka ọgwụgwọ ọrịa afọ dị iche iche. Site na njirimara ya na usoro omume ya pụrụ iche, Linaclotide na-enye ọtụtụ uru na ijikwa mgbakasị obi mgbakasị ahụ (IBS) na afọ ntachi idiopathic na-adịghị ala ala (CIC). Na mgbakwunye, ikike ya na-agbatị ruo nhịahụ nke mgbaze, gastritis, ọnya afọ, ọrịa reflux gastroesophageal (GERD), yana mgbochi na ọgwụgwọ ọnya peptic.
Linaclotide maka ọrịa afọ ọsịsa:
Linaclotide egosila na ọ dị irè n'ịgwọ ọrịa bowel na-agbakasị ahụ na afọ ntachi (IBS-C) na afọ ntachi idiopathic na-adịghị ala ala (CIC). Site na ịba ụba nke mmiri n'ime eriri afọ na ịkwalite mmegharị nke nri site na eriri afọ, Linaclotide na-enyere aka belata mgbaàmà dị ka afọ ntachi, mgbu afọ, ahụ erughị ala, mgbakasị ahụ, na mmetụta nke mmegharị afọ ezughị ezu. Ikike ya ibelata ịgbalite neurons sensory colonic na-ebelata ihe mgbu, ebe ọ na-eme ka neurons moto colon na-abawanye mkpụkọ akwara dị nro ma na-akwalite mmegharị afọ.
Na-ebelata afọ ntachi na gastritis:
Na mgbakwunye na uru ya n'ịchịkwa ọrịa afọ afọ, Linaclotide egosila nkwa na-ebelata ihe mgbaàmà nke mgbaze na gastritis. Site na ibelata iwe iwe, ọnya na afọ ntachi, capsules Linaclotide na-enye ahụ efe pụọ na mmetụta na-adịghị mma. Ọzọkwa, Linaclotide nwere ike ibelata secretion acid gastric ma belata ihe omume nke mbufụt nke afọ, na-enye aka na nkasi obi mgbari nri ka mma.
Ọgwụgwọ ọnya afọ:
A na-eji capsules Linaclotide mee ihe maka ọgwụgwọ ọnya afọ. Site na igbochi secretion acid gastric na ịkwalite usoro ọgwụgwọ, Linaclotide na-enyere aka n'ịrụzi ọnya afọ. Ọ na-ebelatakwa ihe ize ndụ nke nlọghachite ọnya ma mee ka ike nchekwa afọ dịkwuo elu. Njirimara ndị a na-eme Linaclotide ka ọ bụrụ nhọrọ ọgwụgwọ dị irè maka ijikwa na igbochi ọnya afọ.
Enyemaka sitere na Ọrịa Gastroesophageal Reflux (GERD):
Capsules Linaclotide egosipụtala ịdị irè dị ukwuu n'ibelata mgbaàmà metụtara ọrịa reflux gastroesophageal. Nrekasị obi, njigide obi, na ụkwara nke acid reflux kpatara nwere ike iji Linaclotide belata nke ọma. Na mgbakwunye, Linaclotide na-enyere aka n'ịrụzi mucosa esophageal, ibelata mbufụt, na igbochi mmebi ọzọ.
Mgbochi na ọgwụgwọ nke peptic ulcer:
Capsules Linaclotide na-arụ ọrụ dị mkpa n'ịgbochi na ọgwụgwọ ọnya peptic. Site na igbochi secretion acid gastric, Linaclotide na-ebelata ihe omume na nlọghachi nke ọnya. Ọzọkwa, ọ na-akwalite ọgwụgwọ ọnya na-eme ka usoro nrụzi mucosal dịkwuo elu, na-enyere aka n'ịgbake ahụ ike nke afọ.
Mwepu site na agụụ nke agụụ nke Gastritis kpatara:
Achọpụtara Linaclotide na-ebelata agụụ nke agụụ na-ejikọta ya na gastritis. Itsanti-inflammatory Njirimara na-enyere aka belata mbufụt nke afọ ma melite ọrụ mgbaze nke afọ. N'ihi ya, Linaclotide na-akwalite mgbake nke agụụ ma na-abawanye oriri na-eri nri, na-ekwu okwu nke mbelata agụụ nke gastritis kpatara.
Njikwa Mmepụta Acid Gastric:
Otu n'ime uru dị ịrịba ama nke Linaclotide bụ ikike ya ịchịkwa mmepụta acid gastric. Site n'ibelata secretion acid gastric, Linaclotide na-enyere aka ịnọgide na-enwe gburugburu acid-base gburugburu n'ime afọ. Njikwa a na-emepụta mmepụta acid gastric ọ bụghị nanị na-enye aka na ahụike afọ ntachi dum kamakwa ọ na-ejikwa nke ọma ọnọdụ ndị metụtara gastric acid dị ka ọnya afọ na ọrịa reflux gastroesophageal.
Ọzọkwa, a na-eji tadalafil jikwaa ọbara mgbali elu nke akwara ọbara (PAH) n'ime ma ndị nwoke ma ndị nwanyị. N'ime ngwa a, ọ na-enyere aka melite ikike mmega ahụ na igbu oge na-akawanye njọ nke ọrịa ahụ.
Linaclotide, dị ka onye na-ahụ maka peptide agonist nke guanylate cyclase 2C, na-enye ọtụtụ uru maka ọgwụgwọ ọrịa eriri afọ na ahụike eriri afọ. Ikike ya ibelata mgbaàmà nke mgbakasị ahụ na-agbakasị ahụ na afọ ntachi nke idiopathic na-adịghị ala ala eguzobela nke ọma. Ọzọkwa, Linaclotide na-egosi nkwa n'ịbelata afọ ntachi, gastritis, na ọrịa reflux gastroesophageal. Ọ na-ekerekwa òkè dị mkpa na mgbochi na ọgwụgwọ afọ na ọnya peptic. Ọ bụ ezie na Linaclotide na-enye ahụ efe dị ukwuu ma na-akwalite ịdị mma nke eriri afọ, ọ dị mkpa ịkpọtụrụ ndị ọkachamara ahụike maka ojiji kwesịrị ekwesị na nduzi usoro ọgwụgwọ.
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