Dabrafenib Ose Togafitiga Fa'atatau ile BRAF-Mutated Cancers

II. Fa'ailoga Fa'afoma'i:

A. Monotherapy:

Melanoma e le mafai ona fa'asa'o pe fa'a'ese'ese fa'atasi ma suiga ole BRAF V600E

B. Togafitiga tu'ufa'atasi ma le trametinib:

BRAF V600E lelei e le mafai ona fa'asa'oina po'o le metastatic melanoma

Metastatic e le o ni sela laiti o le mama mama

Metastatic anaplastic thyroid cancer

Tula malo e le mafai ona fa'aaogaina pe metastatic

III. Mechanism of Action:

A. Filifilia fusifusia ma faʻalavelave ole B-raf

B. Taofi le fa'atuputeleina o sela tumo ma le ga'o BRAF ua suia

IV. Togafitiga ole Kanesa ole Gaioi:

A. O nisi ituaiga o kanesa o louroid ua sosolo atu i aano o lo'o lata ane po'o isi vaega ole tino

B. Togafitiga muamua(s) tetee

V. Kinase Inhibitor Vasega:

A. Dabrafenib o se sui o kinase inhibitors

B. Puipuia gaioiga fa'aletonu ole polotini e puipuia ai le fa'ateleina ole sela ole kanesa