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Vasopressin Multifaceted Hormone Regulating Fluid Balance

Reference Price:USD 40-100

  • Product Name Vasopressin
  • CAS No. 11000-17-2
  • Appearance White Lyophilized Powder
  • MF C46H65N13O12S2
  • MW 1056.22
  • EINECS 234-236-2
  • Density 1.31g/cm3

Detailed Description

Vasopressin, also known as antidiuretic hormone (ADH), plays a crucial role in regulating fluid osmolality by promoting water reabsorption in the kidneys. This hormone not only induces antidiuretic effects but also exhibits vasoconstrictive properties and affects various organs such as the bowel, gallbladder, and bladder. Vasopressin is used in the treatment of central uremia, polyuria after brain surgery or head trauma, relaxation of abdominal muscles, and as an adjunct in the management of acute hemorrhage. 

Vasopressin acts as the primary regulator of fluid osmolality by increasing water reabsorption in the kidneys. By increasing the permeability of the epithelial cells in the renal collecting ducts, vasopressin promotes water reabsorption, resulting in an antidiuretic effect. Additionally, it exhibits vasoconstrictive properties, constricting the peripheral vasculature, and induces constriction of the bowel, gallbladder, and bladder.


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In the treatment of central uremia, vasopressin is used to manage the symptoms associated with pressin deficiency, such as copious amounts of watery urine and increased thirst. It helps restore the balance of body fluid osmolality by increasing water reabsorption in the renal tubular collecting ducts, leading to a decrease in urine production and concentration of sodium in the urine.

Vasopressin is also utilized in the initial treatment of polyuria after brain surgery or head trauma. By regulating fluid balance, vasopressin assists in reducing excessive urine production and maintaining proper hydration.

Furthermore, vasopressin finds application in relaxing abdominal muscles when other drugs are ineffective. Its ability to induce vasoconstriction and affect smooth muscle contraction provides relief in certain conditions where muscle relaxation is required.

In acute hemorrhage caused by diseases of the esophagus, gastrointestinal tract, and other digestive tracts, vasopressin can be used as an adjunct in the treatment. Its vasoconstrictive properties help in reducing bleeding and stabilizing the patient's condition.
Vasopressin is synthesized centrally in the hypothalamus as a cyclic nonapeptide. It participates in the hypothalamic-pituitary-adrenal axis and regulates pituitary corticotropin secretion by enhancing the effects of corticotropin-releasing factor. Additionally, vasopressin acts as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors.

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Vasopressin, also known as antidiuretic hormone, plays a vital role in regulating fluid balance in the body. Its ability to induce water reabsorption, vasoconstriction, and affect various organs makes it a versatile hormone with multiple therapeutic applications. From managing central uremia and polyuria to aiding in abdominal muscle relaxation and controlling acute hemorrhage, vasopressin demonstrates its efficacy in various clinical scenarios. 

Specification

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