0102030405
Vincristine Sulfate Powder Vincristine Purity Vincristine CAS 57-22-7
Detailed Description
Vincristine is a white to off-white crystalline powder.It is practically insoluble in water,but it dissolves in some organic solvents.The pure compound is odorless and is typically stored in a dry,dark place under controlled temperature conditions to maintain its stability.It is a naturally occurring alkaloid derived from the Madagascar periwinkle plant(Catharanthus roseus).Its chemical structure resembles that of vinblastine,another vinca alkaloid.Vincristine is widely used in the treatment of various types of cancer,including leukemia,lymphoma,and solid tumors.
Vincristine is a microtubule inhibitor that disrupts the formation of microtubules,which are essential components of the cell's cytoskeleton.By binding to tubulin,it prevents the assembly of microtubules,leading to mitotic arrest and cell death in actively dividing cells.This mechanism of action makes vincristine particularly effective against rapidly dividing cancer cells.Clinical applications of vincristine include the treatment of various malignancies such as acute lymphoblastic leukemia(ALL),Hodgkin's and non-Hodgkin's lymphomas,pediatric and adult solid tumors,neuroblastoma,and rhabdomyosarcoma.Vincristine is often used in combination with other chemotherapeutic agents as part of multi-drug treatment regimens,collectively known as combination chemotherapy.
In addition to its primary use in cancer treatment,vincristine has also demonstrated efficacy in the management of certain non-oncological conditions.It is used in the treatment of idiopathic thrombocytopenic purpura(ITP),an autoimmune disorder characterized by a low platelet count.Furthermore,vincristine has shown potential in the management of various neurological conditions,including chronic inflammatory demyelinating polyneuropathy(CIDP)and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections(PANDAS).
Furthermore,vincristine's anti-angiogenic properties have led to exploration of its potential use in the treatment of various proliferative disorders,including diabetic retinopathy and age-related macular degeneration.However,vincristine is primarily known for its role in cancer treatment,and its use in other medical conditions is considered off-label and requires careful evaluation of potential risks and benefits.In summary,vincristine,derived from the Madagascar periwinkle plant,is a valuable anti-cancer agent that disrupts microtubule formation and induces cell death in dividing cells.Its wide-ranging clinical applications include the treatment of leukemia,lymphoma,solid tumors,and certain non-oncological conditions.While its primary use is in cancer therapy,ongoing research continues to explore its potential in diverse medical conditions.
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